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Items: 1 to 20 of 233

1.

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.

Gotoh N.

Cancer Sci. 2008 Jul;99(7):1319-25. doi: 10.1111/j.1349-7006.2008.00840.x. Epub 2008 Apr 29. Review.

2.

Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.

Huang L, Watanabe M, Chikamori M, Kido Y, Yamamoto T, Shibuya M, Gotoh N, Tsuchida N.

Oncogene. 2006 Oct 19;25(49):6457-66. Epub 2006 May 15.

PMID:
16702953
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Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.

Hanafusa H, Torii S, Yasunaga T, Nishida E.

Nat Cell Biol. 2002 Nov;4(11):850-8.

PMID:
12402043
6.

Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling.

Zhang T, Ma J, Cao X.

Biochem J. 2003 Dec 1;376(Pt 2):457-64.

7.

Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells.

Manuvakhova M, Thottassery JV, Hays S, Qu Z, Rentz SS, Westbrook L, Kern FG.

Oncogene. 2006 Sep 28;25(44):6003-14. Epub 2006 May 8.

PMID:
16682955
8.

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

Wu Y, Chen Z, Ullrich A.

Biol Chem. 2003 Aug;384(8):1215-26.

PMID:
12974390
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10.

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6074-9. Epub 2001 May 15.

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Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.

Araki T, Nawa H, Neel BG.

J Biol Chem. 2003 Oct 24;278(43):41677-84. Epub 2003 Aug 14.

13.

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.

Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J.

Cell. 1997 May 30;89(5):693-702.

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Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.

Yamada M, Suzuki K, Mizutani M, Asada A, Matozaki T, Ikeuchi T, Koizumi S, Hatanaka H.

J Biochem. 2001 Jul;130(1):157-65.

17.

Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.

Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A.

J Mol Biol. 2002 Feb 1;315(5):1167-77.

PMID:
11827484
18.

FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.

Iejima D, Minegishi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N.

Oncogene. 2010 May 27;29(21):3087-99. doi: 10.1038/onc.2010.69. Epub 2010 Mar 15.

PMID:
20228838
19.

FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway.

Zhou W, Feng X, Wu Y, Benge J, Zhang Z, Chen Z.

Cell Res. 2009 Oct;19(10):1165-77. doi: 10.1038/cr.2009.95. Epub 2009 Aug 4.

PMID:
19652666
20.

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

Roskoski R Jr.

Biochem Biophys Res Commun. 2005 Nov 11;337(1):1-13. Review.

PMID:
16129412

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