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Items: 1 to 20 of 105

1.

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation.

McGinty RK, Kim J, Chatterjee C, Roeder RG, Muir TW.

Nature. 2008 Jun 5;453(7196):812-6. doi: 10.1038/nature06906. Epub 2008 Apr 30.

2.

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW.

ACS Chem Biol. 2009 Nov 20;4(11):958-68. doi: 10.1021/cb9002255.

3.

Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.

Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW.

Nat Commun. 2016 Feb 2;7:10589. doi: 10.1038/ncomms10589.

4.

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

Ng HH, Xu RM, Zhang Y, Struhl K.

J Biol Chem. 2002 Sep 20;277(38):34655-7. Epub 2002 Aug 6.

5.

hDOT1L links histone methylation to leukemogenesis.

Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y.

Cell. 2005 Apr 22;121(2):167-78. Erratum in: Cell. 2005 Jun 3;121(5):809.

6.

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.

Feng Q, Wang H, Ng HH, Erdjument-Bromage H, Tempst P, Struhl K, Zhang Y.

Curr Biol. 2002 Jun 25;12(12):1052-8.

7.

Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis.

Li J, He Q, Liu Y, Liu S, Tang S, Li C, Sun D, Li X, Zhou M, Zhu P, Bi G, Zhou Z, Zheng JS, Tian C.

Chembiochem. 2017 Jan 17;18(2):176-180. doi: 10.1002/cbic.201600551. Epub 2016 Dec 15.

PMID:
27976477
8.

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast.

Sun ZW, Allis CD.

Nature. 2002 Jul 4;418(6893):104-8. Epub 2002 Jun 23.

PMID:
12077605
9.

Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.

Shahbazian MD, Zhang K, Grunstein M.

Mol Cell. 2005 Jul 22;19(2):271-7.

10.

Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation.

Foster ER, Downs JA.

J Cell Biol. 2009 Mar 9;184(5):631-8. doi: 10.1083/jcb.200812088. Epub 2009 Mar 2.

11.

Trypanosome H2Bv replaces H2B in nucleosomes enriched for H3 K4 and K76 trimethylation.

Mandava V, Janzen CJ, Cross GA.

Biochem Biophys Res Commun. 2008 Apr 18;368(4):846-51. doi: 10.1016/j.bbrc.2008.01.144. Epub 2008 Feb 7.

12.

Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis.

Fierz B, Kilic S, Hieb AR, Luger K, Muir TW.

J Am Chem Soc. 2012 Dec 5;134(48):19548-51. doi: 10.1021/ja308908p. Epub 2012 Nov 26.

13.

Making and Breaking Ubiquitin.

Muir TW, McGinty R, Pratt M, Chatterjee C, Schwartz E.

FASEB J. 2002 Mar;22(1_supplement):4113. doi: 10.1096/fasebj.22.1_supplement.411.3.

PMID:
29430986
14.

Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.

Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD.

J Biol Chem. 2012 Jul 6;287(28):23718-25. doi: 10.1074/jbc.M112.361824. Epub 2012 May 22.

15.

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation.

Tanny JC, Erdjument-Bromage H, Tempst P, Allis CD.

Genes Dev. 2007 Apr 1;21(7):835-47. Epub 2007 Mar 20.

16.
17.

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10365-70. doi: 10.1073/pnas.1504483112. Epub 2015 Aug 3.

18.

Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.

Chen Z, Grzybowski AT, Ruthenburg AJ.

Chembiochem. 2014 Sep 22;15(14):2071-5. doi: 10.1002/cbic.201402313. Epub 2014 Aug 22.

19.

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

Chatterjee C, McGinty RK, Fierz B, Muir TW.

Nat Chem Biol. 2010 Apr;6(4):267-9. doi: 10.1038/nchembio.315. Epub 2010 Mar 7.

PMID:
20208522
20.

Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation.

Chandrasekharan MB, Huang F, Sun ZW.

Epigenetics. 2010 Aug 16;5(6):460-8. doi: 10.4161/epi.5.6.12314. Epub 2010 Aug 16. Review.

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