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Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2838-44. doi: 10.1152/ajpheart.00186.2008. Epub 2008 Apr 25.


Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo.

Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Iliff J, Alkayed NJ, Van Winkle DM.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2128-34. doi: 10.1152/ajpheart.00428.2008. Epub 2008 Oct 3.


Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog.

Gross GJ, Gauthier KM, Moore J, Campbell WB, Falck JR, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H47-52. doi: 10.1152/ajpheart.01084.2008. Epub 2009 May 15.


Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts.

Gross GJ, Baker JE, Moore J, Falck JR, Nithipatikom K.

Cardiovasc Drugs Ther. 2011 Dec;25(6):517-22. doi: 10.1007/s10557-011-6321-9.


Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.

Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.

Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H537-42. Epub 2006 Feb 10.


Soluble epoxide hydrolase: a new target for cardioprotection.

Gross GJ, Nithipatikom K.

Curr Opin Investig Drugs. 2009 Mar;10(3):253-8. Review.


Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.

Gross GJ, Hsu A, Falck JR, Nithipatikom K.

J Mol Cell Cardiol. 2007 Mar;42(3):687-91. Epub 2007 Jan 10.


Novel soluble epoxide hydrolase inhibitor protects mitochondrial function following stress.

Batchu SN, Lee SB, Samokhvalov V, Chaudhary KR, El-Sikhry H, Weldon SM, Seubert JM.

Can J Physiol Pharmacol. 2012 Jun;90(6):811-23. doi: 10.1139/y2012-082. Epub 2012 May 24.


Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.

Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2201-7. doi: 10.1152/ajpheart.00815.2009. Epub 2010 Apr 16.


Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Katragadda D, Batchu SN, Cho WJ, Chaudhary KR, Falck JR, Seubert JM.

J Mol Cell Cardiol. 2009 Jun;46(6):867-75. doi: 10.1016/j.yjmcc.2009.02.028. Epub 2009 Mar 12.


Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure.

Merabet N, Bellien J, Glevarec E, Nicol L, Lucas D, Remy-Jouet I, Bounoure F, Dreano Y, Wecker D, Thuillez C, Mulder P.

J Mol Cell Cardiol. 2012 Mar;52(3):660-6. doi: 10.1016/j.yjmcc.2011.11.015. Epub 2011 Dec 6.


14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries.

Bukhari IA, Gauthier KM, Jagadeesh SG, Sangras B, Falck JR, Campbell WB.

J Pharmacol Exp Ther. 2011 Jan;336(1):47-55. doi: 10.1124/jpet.110.169797. Epub 2010 Sep 29.


Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.

Gross GJ, Hsu A, Gross ER, Falck JR, Nithipatikom K.

J Cardiovasc Pharmacol Ther. 2013 Jan;18(1):38-45. doi: 10.1177/1074248412437586. Epub 2012 Mar 9.


Epoxyeicosanoid Signaling Provides Multi-target Protective Effects on Neurovascular Unit in Rats After Focal Ischemia.

Liu Y, Wan Y, Fang Y, Yao E, Xu S, Ning Q, Zhang G, Wang W, Huang X, Xie M.

J Mol Neurosci. 2016 Feb;58(2):254-65. doi: 10.1007/s12031-015-0670-y. Epub 2015 Nov 6.


Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARĪ³.

Nayeem MA, Pradhan I, Mustafa SJ, Morisseau C, Falck JR, Zeldin DC.

Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R23-32. doi: 10.1152/ajpregu.00213.2012. Epub 2012 Nov 14.


Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels.

Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD.

J Pharmacol Exp Ther. 2006 Sep;318(3):1307-14. Epub 2006 Jun 13.


Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.

Mozaffari MS, Schaffer SW.

Am J Hypertens. 2008 May;21(5):570-5. doi: 10.1038/ajh.2008.25. Epub 2008 Mar 20.


Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.

Batchu SN, Lee SB, Qadhi RS, Chaudhary KR, El-Sikhry H, Kodela R, Falck JR, Seubert JM.

Br J Pharmacol. 2011 Feb;162(4):897-907. doi: 10.1111/j.1476-5381.2010.01093.x.

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