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Items: 1 to 20 of 89

1.

Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.

Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, Salem RM, Shih PA, Das M, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, O'Connor DT.

Kidney Int. 2008 Jul;74(1):115-25. doi: 10.1038/ki.2008.113. Epub 2008 Apr 23. Erratum in: Kidney Int. 2009 Jun;75(11):1237.

2.

Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins.

Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT.

Am J Hypertens. 2012 Jan;25(1):29-40. doi: 10.1038/ajh.2011.163. Epub 2011 Sep 15.

3.

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT.

J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81. doi: 10.1016/j.jacc.2008.07.047.

4.

A haplotype variant of the human chromogranin A gene (CHGA) promoter increases CHGA expression and the risk for cardiometabolic disorders.

Subramanian L, Khan AA, Allu PKR, Kiranmayi M, Sahu BS, Sharma S, Khullar M, Mullasari AS, Mahapatra NR.

J Biol Chem. 2017 Aug 25;292(34):13970-13985. doi: 10.1074/jbc.M117.778134. Epub 2017 Jun 30.

PMID:
28667172
5.

Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.

Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT.

J Am Coll Cardiol. 2009 Sep 1;54(10):944-54. doi: 10.1016/j.jacc.2009.05.035. Erratum in: J Am Coll Cardiol. 2009 Oct 6;54(15):1482.

6.

Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension.

Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton BA, Ziegler MG, Mahata SK, O'Connor DT.

Circulation. 2007 May 1;115(17):2271-81. Epub 2007 Apr 16.

7.

Proteomic analysis yields an unexpected trans-acting point in control of the human sympathochromaffin phenotype.

Chiron S, Wei Z, Chen Y, Zhang K, Wen G, Fischer WH, Mahata SK, O'Connor DT.

Circ Cardiovasc Genet. 2011 Aug 1;4(4):437-45. doi: 10.1161/CIRCGENETICS.110.957886. Epub 2011 May 6.

8.

Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.

Lillie EO, Mahata M, Khandrika S, Rao F, Bundey RA, Wen G, Chen Y, Taupenot L, Smith DW, Mahata SK, Ziegler MG, Cockburn M, Schork NJ, O'Connor DT.

Circulation. 2007 May 1;115(17):2282-91. Epub 2007 Apr 16.

9.

Adrenergic polymorphism and the human stress response.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Ann N Y Acad Sci. 2008 Dec;1148:282-96. doi: 10.1196/annals.1410.085.

10.

Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.

Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata SK, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork NJ, O'Connor DT, Taylor P.

J Pharmacol Exp Ther. 2009 Nov;331(2):419-28. doi: 10.1124/jpet.109.157271. Epub 2009 Aug 11.

11.

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.

Friese RS, Altshuler AE, Zhang K, Miramontes-Gonzalez JP, Hightower CM, Jirout ML, Salem RM, Gayen JR, Mahapatra NR, Biswas N, Cale M, Vaingankar SM, Kim HS, Courel M, Taupenot L, Ziegler MG, Schork NJ, Pravenec M, Mahata SK, Schmid-Schönbein GW, O'Connor DT.

Hum Mol Genet. 2013 Sep 15;22(18):3624-40. doi: 10.1093/hmg/ddt213. Epub 2013 May 13.

12.

Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107.

Zhang K, Mir SA, Hightower CM, Miramontes-Gonzalez JP, Maihofer AX, Chen Y, Mahata SK, Nievergelt CM, Schork NJ, Freedman BI, Vaingankar SM, O'Connor DT.

J Am Soc Nephrol. 2015 Aug;26(8):1816-25. doi: 10.1681/ASN.2014060537. Epub 2014 Nov 12.

13.

Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Circulation. 2007 Aug 28;116(9):993-1006. Epub 2007 Aug 13.

14.

Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.

Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT.

J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. Erratum in: J Am Coll Cardiol. 2012 Nov 20;60(21):2261.

15.

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.

Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton BA, O'Connor DT.

J Hypertens. 2010 Jan;28(1):76-86. doi: 10.1097/HJH.0b013e328332bc87.

16.

Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.

Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton BA, O'Connor DT.

Cell Mol Neurobiol. 2010 Nov;30(8):1395-400. doi: 10.1007/s10571-010-9600-2.

17.

Chromogranin A polymorphisms are associated with hypertensive renal disease.

Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton BA, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT.

J Am Soc Nephrol. 2008 Mar;19(3):600-14. doi: 10.1681/ASN.2007070754. Epub 2008 Jan 30.

18.

Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion.

Greenwood TA, Rao F, Stridsberg M, Mahapatra NR, Mahata M, Lillie EO, Mahata SK, Taupenot L, Schork NJ, O'Connor DT.

Physiol Genomics. 2006 May 16;25(3):470-9. Epub 2006 Mar 22.

19.

A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population.

Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K.

Endocr J. 2015;62(9):797-804. doi: 10.1507/endocrj.EJ14-0471. Epub 2015 Jul 25.

20.

Analysis and validation of traits associated with a single nucleotide polymorphism Gly364Ser in catestatin using humanized chromogranin A mouse models.

Mir SA, Zhang K, Milic M, Gu Y, Rieg T, Ziegler M, Vaingankar SM.

J Hypertens. 2016 Jan;34(1):68-78. doi: 10.1097/HJH.0000000000000760.

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