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C5 deficiency and C5a or C5aR blockade protects against cerebral malaria.

Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC.

J Exp Med. 2008 May 12;205(5):1133-43. doi: 10.1084/jem.20072248. Epub 2008 Apr 21.


A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration.

Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD.

J Immunol. 2001 Feb 15;166(4):2479-86.


C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression.

Xu GL, Chen J, Yang F, Li GQ, Zheng LX, Wu YZ.

Hepatology. 2014 Jul;60(1):114-24. doi: 10.1002/hep.27114. Epub 2014 May 28.


Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria.

Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC.

Infect Immun. 2014 Jan;82(1):371-9. doi: 10.1128/IAI.01246-13. Epub 2013 Nov 4.


A novel role for the fifth component of complement (C5) in cardiac physiology.

Mullick A, Tremblay J, Leon Z, Gros P.

PLoS One. 2011;6(8):e22919. doi: 10.1371/journal.pone.0022919. Epub 2011 Aug 1.


Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria.

Engwerda CR, Mynott TL, Sawhney S, De Souza JB, Bickle QD, Kaye PM.

J Exp Med. 2002 May 20;195(10):1371-7.


Hypersusceptibility of A/J mice to tuberculosis is in part due to a deficiency of the fifth complement component (C5).

Jagannath C, Hoffmann H, Sepulveda E, Actor JK, Wetsel RA, Hunter RL.

Scand J Immunol. 2000 Oct;52(4):369-79.


CCR5 deficiency decreases susceptibility to experimental cerebral malaria.

Belnoue E, Kayibanda M, Deschemin JC, Viguier M, Mack M, Kuziel WA, Rénia L.

Blood. 2003 Jun 1;101(11):4253-9. Epub 2003 Jan 30.


Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma.

Karp CL, Grupe A, Schadt E, Ewart SL, Keane-Moore M, Cuomo PJ, Köhl J, Wahl L, Kuperman D, Germer S, Aud D, Peltz G, Wills-Karp M.

Nat Immunol. 2000 Sep;1(3):221-6.


C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies.

Romay-Penabad Z, Liu XX, Montiel-Manzano G, Papalardo De Martínez E, Pierangeli SS.

Ann N Y Acad Sci. 2007 Jun;1108:554-66.


Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice.

Delahaye NF, Coltel N, Puthier D, Flori L, Houlgatte R, Iraqi FA, Nguyen C, Grau GE, Rihet P.

J Infect Dis. 2006 Jan 15;193(2):312-21. Epub 2005 Dec 5.


Role of complement components in the susceptibility to Plasmodium berghei infection among inbred strains of mice.

Williams AI, Rosen FS, Hoff R.

Ann Trop Med Parasitol. 1975 Jun;69(2):179-85.


Contribution of C5-mediated mechanisms to host defence against Echinococcus granulosus hydatid infection.

Ferreira AM, Breijo M, Sim RB, Nieto A.

Parasite Immunol. 2000 Sep;22(9):445-53.


Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions.

Pasinetti GM, Tocco G, Sakhi S, Musleh WD, DeSimoni MG, Mascarucci P, Schreiber S, Baudry M, Finch CE.

Neurobiol Dis. 1996;3(3):197-204.


Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis.

Lalli PN, Strainic MG, Yang M, Lin F, Medof ME, Heeger PS.

Blood. 2008 Sep 1;112(5):1759-66. doi: 10.1182/blood-2008-04-151068. Epub 2008 Jun 20.


The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.

Mukherjee P, Pasinetti GM.

J Neuroimmunol. 2000 Jun 26;105(2):124-30. Review.


Further characterization of the curative antibodies in Trypanosoma musculi infection.

Wechsler DS, Kongshavn PA.

Infect Immun. 1988 Sep;56(9):2379-84.


Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host.

Griffith JW, O'Connor C, Bernard K, Town T, Goldstein DR, Bucala R.

J Infect Dis. 2007 Nov 15;196(10):1553-64. Epub 2007 Oct 31.


Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation.

Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegård KT, Köhl J, Lambris JD.

Blood. 2002 Sep 1;100(5):1869-77. Erratum in: Blood 2002 Oct 15;100(8):2691.

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