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Items: 1 to 20 of 113


Frabin and other related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membrane.

Nakanishi H, Takai Y.

J Cell Mol Med. 2008 Aug;12(4):1169-76. doi: 10.1111/j.1582-4934.2008.00345.x. Epub 2008 Apr 9. Review.


Association of frabin with specific actin and membrane structures.

Kim Y, Ikeda W, Nakanishi H, Tanaka Y, Takekuni K, Itoh S, Monden M, Takai Y.

Genes Cells. 2002 Apr;7(4):413-20.


Importance of spatial activation of Cdc42 and rac small G proteins by frabin for microspike formation in MDCK cells.

Yasuda T, Ohtsuka T, Inoue E, Yokoyama S, Sakisaka T, Kodama A, Takaishi K, Takai Y.

Genes Cells. 2000 Jul;5(7):583-91.


Cooperation of Cdc42 small G protein-activating and actin filament-binding activities of frabin in microspike formation.

Ikeda W, Nakanishi H, Tanaka Y, Tachibana K, Takai Y.

Oncogene. 2001 Jun 14;20(27):3457-63.


Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge.

Ko HK, Guo LW, Su B, Gao L, Gelman IH.

PLoS One. 2014 Oct 30;9(10):e111534. doi: 10.1371/journal.pone.0111534. eCollection 2014.


Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac.

Ono Y, Nakanishi H, Nishimura M, Kakizaki M, Takahashi K, Miyahara M, Satoh-Horikawa K, Mandai K, Takai Y.

Oncogene. 2000 Jun 22;19(27):3050-8.


Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein.

Umikawa M, Obaishi H, Nakanishi H, Satoh-Horikawa K, Takahashi K, Hotta I, Matsuura Y, Takai Y.

J Biol Chem. 1999 Sep 3;274(36):25197-200.


Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.

Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL.

Hum Mol Genet. 2003 Aug 15;12(16):1981-93.


Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

Filipenko NR, Attwell S, Roskelley C, Dedhar S.

Oncogene. 2005 Sep 1;24(38):5837-49.


Frabin, a novel FGD1-related actin filament-binding protein capable of changing cell shape and activating c-Jun N-terminal kinase.

Obaishi H, Nakanishi H, Mandai K, Satoh K, Satoh A, Takahashi K, Miyahara M, Nishioka H, Takaishi K, Takai Y.

J Biol Chem. 1998 Jul 24;273(30):18697-700.


Identification of splicing variants of Frabin with partly different functions and tissue distribution.

Ikeda W, Nakanishi H, Takekuni K, Itoh S, Takai Y.

Biochem Biophys Res Commun. 2001 Sep 7;286(5):1066-72.


A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.

Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M.

J Biol Chem. 2003 Apr 11;278(15):13207-15. Epub 2003 Jan 23.


Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.

Chen XM, Splinter PL, Tietz PS, Huang BQ, Billadeau DD, LaRusso NF.

J Biol Chem. 2004 Jul 23;279(30):31671-8. Epub 2004 May 7.


The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.

Banerjee J, Fischer CC, Wedegaertner PB.

Biochemistry. 2009 Aug 25;48(33):8032-43. doi: 10.1021/bi9010013.


The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin.

Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A.

Nat Cell Biol. 2000 Dec;2(12):888-92.


Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins.

Meller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA.

Nat Cell Biol. 2002 Sep;4(9):639-47.


Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.

Reid T, Bathoorn A, Ahmadian MR, Collard JG.

J Biol Chem. 1999 Nov 19;274(47):33587-93.

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