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Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex.

Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T.

Cell Host Microbe. 2008 Apr 17;3(4):253-62. doi: 10.1016/j.chom.2008.03.002.


Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.

Bai Y, Xuan B, Liu H, Zhong J, Yu D, Qian Z.

J Virol. 2015 Aug;89(15):7625-35. doi: 10.1128/JVI.01027-15. Epub 2015 May 13.


The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activation.

Qian Z, Xuan B, Gualberto N, Yu D.

J Virol. 2011 Sep;85(17):9103-13. doi: 10.1128/JVI.00572-11. Epub 2011 Jun 29. Erratum in: J Virol. 2011 Oct;85(20):10932.


Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism.

Sun Y, Bao Q, Xuan B, Xu W, Pan D, Li Q, Qian Z.

J Virol. 2018 Jun 13;92(13). pii: e00191-18. doi: 10.1128/JVI.00191-18. Print 2018 Jul 1.


Human cytomegalovirus UL38 protein blocks apoptosis.

Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D.

J Virol. 2007 Apr;81(7):3109-23. Epub 2007 Jan 3.


Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection.

Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS.

J Virol. 2013 Mar;87(5):2463-74. doi: 10.1128/JVI.01926-12. Epub 2012 Dec 12.


Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.

Bilanges B, Argonza-Barrett R, Kolesnichenko M, Skinner C, Nair M, Chen M, Stokoe D.

Mol Cell Biol. 2007 Aug;27(16):5746-64. Epub 2007 Jun 11.


mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19384-9. doi: 10.1073/pnas.0810584105. Epub 2008 Dec 3.


The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2.

Rodríguez-Sánchez I, Schafer XL, Monaghan M, Munger J.

PLoS Pathog. 2019 Jan 24;15(1):e1007569. doi: 10.1371/journal.ppat.1007569. eCollection 2019 Jan.


Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA.

Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T.

PLoS Pathog. 2010 Jun 24;6(6):e1000965. doi: 10.1371/journal.ppat.1000965.


The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.


Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

Huang J, Wu S, Wu CL, Manning BD.

Cancer Res. 2009 Aug 1;69(15):6107-14. doi: 10.1158/0008-5472.CAN-09-0975. Epub 2009 Jul 14.


The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.

Huang J, Manning BD.

Biochem J. 2008 Jun 1;412(2):179-90. doi: 10.1042/BJ20080281. Review.


Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication.

Moorman NJ, Shenk T.

J Virol. 2010 May;84(10):5260-9. doi: 10.1128/JVI.02733-09. Epub 2010 Feb 24.


The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits.

Hoogeveen-Westerveld M, van Unen L, van den Ouweland A, Halley D, Hoogeveen A, Nellist M.

BMC Biochem. 2012 Sep 24;13:18. doi: 10.1186/1471-2091-13-18.


TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.

Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD.

Mol Cell. 2012 Aug 24;47(4):535-46. doi: 10.1016/j.molcel.2012.06.009. Epub 2012 Jul 12.


Functional assessment of TSC2 variants identified in individuals with tuberous sclerosis complex.

Hoogeveen-Westerveld M, Ekong R, Povey S, Mayer K, Lannoy N, Elmslie F, Bebin M, Dies K, Thompson C, Sparagana SP, Davies P, van Eeghen AM, Thiele EA, van den Ouweland A, Halley D, Nellist M.

Hum Mutat. 2013 Jan;34(1):167-75. doi: 10.1002/humu.22202. Epub 2012 Oct 11. Erratum in: Hum Mutat. 2013 Feb;34(2):408-10. van Eeghen, Agnies M [added]; Thiele, Elizabeth A [added].


A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.

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