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TIEG-null mice display an osteopenic gender-specific phenotype.

Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M.

Bone. 2008 Jun;42(6):1025-31. doi: 10.1016/j.bone.2008.02.004. Epub 2008 Mar 4.


TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture.

Bensamoun SF, Hawse JR, Subramaniam M, Ilharreborde B, Bassillais A, Benhamou CL, Fraser DG, Oursler MJ, Amadio PC, An KN, Spelsberg TC.

Bone. 2006 Dec;39(6):1244-51. Epub 2006 Jul 28.


TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts.

Subramaniam M, Hawse JR, Bruinsma ES, Grygo SB, Cicek M, Oursler MJ, Spelsberg TC.

Biochem Biophys Res Commun. 2010 Jan 29;392(1):72-6. doi: 10.1016/j.bbrc.2009.12.171. Epub 2010 Jan 6.


TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro.

Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC.

Mol Cell Biol. 2005 Feb;25(3):1191-9.


TGFβ inducible early gene-1 plays an important role in mediating estrogen signaling in the skeleton.

Hawse JR, Pitel KS, Cicek M, Philbrick KA, Gingery A, Peters KD, Syed FA, Ingle JN, Suman VJ, Iwaniec UT, Turner RT, Spelsberg TC, Subramaniam M.

J Bone Miner Res. 2014;29(5):1206-16. doi: 10.1002/jbmr.2142.


Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.

Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC.

J Cell Biochem. 2002;87(2):233-41.


TIEG1 enhances Osterix expression and mediates its induction by TGFβ and BMP2 in osteoblasts.

Subramaniam M, Pitel KS, Withers SG, Drissi H, Hawse JR.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):528-533. doi: 10.1016/j.bbrc.2016.01.112. Epub 2016 Jan 20.


TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway.

Rajamannan NM, Subramaniam M, Abraham TP, Vasile VC, Ackerman MJ, Monroe DG, Chew TL, Spelsberg TC.

J Cell Biochem. 2007 Feb 1;100(2):315-25.


Osteoblast-targeted overexpression of TAZ increases bone mass in vivo.

Yang JY, Cho SW, An JH, Jung JY, Kim SW, Kim SY, Kim JE, Shin CS.

PLoS One. 2013;8(2):e56585. doi: 10.1371/journal.pone.0056585. Epub 2013 Feb 18.


TIEG and estrogen modulate SOST expression in the murine skeleton.

Subramaniam M, Pitel KS, Bruinsma ES, Monroe DG, Hawse JR.

J Cell Physiol. 2018 Apr;233(4):3540-3551. doi: 10.1002/jcp.26211. Epub 2017 Nov 24.


Disruption of four-and-a-half LIM 2 decreases bone mineral content and bone mineral density in femur and tibia bones of female mice.

Govoni KE, Baylink DJ, Chen J, Mohan S.

Calcif Tissue Int. 2006 Aug;79(2):112-7. Epub 2006 Aug 15.


Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene.

Subramaniam M, Hefferan TE, Tau K, Peus D, Pittelkow M, Jalal S, Riggs BL, Roche P, Spelsberg TC.

J Cell Biochem. 1998 Feb 1;68(2):226-36.


Effect of TGF-beta inducible early gene deficiency on flexor tendon healing.

Tsubone T, Moran SL, Subramaniam M, Amadio PC, Spelsberg TC, An KN.

J Orthop Res. 2006 Mar;24(3):569-75.


TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.

Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC.

Oncogene. 2002 Aug 22;21(37):5783-90.


Marfan-like skeletal phenotype in the tight skin (Tsk) mouse.

Barisic-Dujmovic T, Boban I, Adams DJ, Clark SH.

Calcif Tissue Int. 2007 Oct;81(4):305-15. Epub 2007 Aug 19.


The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction.

Xing Y, Gu Y, Bresnahan JJ, Paul EM, Donahue HJ, You J.

PLoS One. 2014 Sep 30;9(9):e108417. doi: 10.1371/journal.pone.0108417. eCollection 2014.


Increased bone mass in mice lacking the adipokine apelin.

Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson RA.

Endocrinology. 2013 Jun;154(6):2069-80. doi: 10.1210/en.2012-2034. Epub 2013 Apr 12.


Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise.

Mohan S, Wergedal JE, Das S, Kesavan C.

Physiol Genomics. 2015 Feb;47(2):33-43. doi: 10.1152/physiolgenomics.00107.2014. Epub 2014 Dec 9.


The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis.

Borton AJ, Frederick JP, Datto MB, Wang XF, Weinstein RS.

J Bone Miner Res. 2001 Oct;16(10):1754-64.


Skeletal phenotype of growing transgenic mice that express a function-perturbing form of beta1 integrin in osteoblasts.

Globus RK, Amblard D, Nishimura Y, Iwaniec UT, Kim JB, Almeida EA, Damsky CD, Wronski TJ, van der Meulen MC.

Calcif Tissue Int. 2005 Jan;76(1):39-49. Epub 2004 Oct 14.


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