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Items: 1 to 20 of 156

1.

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.

2.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

3.

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK.

Endocrinology. 2009 Nov;150(11):4874-82. doi: 10.1210/en.2009-0454. Epub 2009 Oct 9.

4.

PI3K integrates the action of insulin and leptin on hypothalamic neurons.

Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS.

J Clin Invest. 2005 Apr;115(4):951-8. Epub 2005 Mar 10.

5.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.

6.

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.

Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ.

Cell Metab. 2009 Nov;10(5):343-54. doi: 10.1016/j.cmet.2009.09.008.

7.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ.

J Clin Invest. 2007 Aug;117(8):2325-36.

8.

Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47. doi: 10.1152/ajpregu.00131.2014. Epub 2014 Oct 22.

9.

The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus.

Williams KW, Sohn JW, Donato J Jr, Lee CE, Zhao JJ, Elmquist JK, Elias CF.

J Neurosci. 2011 Sep 14;31(37):13147-56. doi: 10.1523/JNEUROSCI.2602-11.2011.

10.

Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons.

Williams KW, Margatho LO, Lee CE, Choi M, Lee S, Scott MM, Elias CF, Elmquist JK.

J Neurosci. 2010 Feb 17;30(7):2472-9. doi: 10.1523/JNEUROSCI.3118-09.2010.

11.

Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response.

Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS.

Endocrinology. 2012 Apr;153(4):1817-26. doi: 10.1210/en.2011-1882. Epub 2012 Feb 14.

PMID:
22334718
12.

Leptin excites proopiomelanocortin neurons via activation of TRPC channels.

Qiu J, Fang Y, Rønnekleiv OK, Kelly MJ.

J Neurosci. 2010 Jan 27;30(4):1560-5. doi: 10.1523/JNEUROSCI.4816-09.2010.

13.

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

Berglund ED, Vianna CR, Donato J Jr, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK.

J Clin Invest. 2012 Mar;122(3):1000-9. doi: 10.1172/JCI59816. Epub 2012 Feb 13.

14.

The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis.

Shi H, Sorrell JE, Clegg DJ, Woods SC, Seeley RJ.

Physiol Behav. 2010 May 11;100(2):165-72. doi: 10.1016/j.physbeh.2010.02.018. Epub 2010 Mar 1.

15.

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB.

Neuron. 2004 Jun 24;42(6):983-91.

16.

Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.

Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP.

Diabetes. 2017 Apr;66(4):920-934. doi: 10.2337/db16-0482. Epub 2017 Jan 10.

PMID:
28073831
17.

Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.

Mercer AJ, Stuart RC, Attard CA, Otero-Corchon V, Nillni EA, Low MJ.

Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E904-15. doi: 10.1152/ajpendo.00540.2013. Epub 2014 Feb 11.

18.

Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.

De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1002-11. doi: 10.1152/ajpendo.00639.2010. Epub 2011 Mar 15.

19.

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring.

Silva JP, Lambert G, van Booven D, Wahlestedt C.

Genome Med. 2016 Sep 8;8(1):93. doi: 10.1186/s13073-016-0348-2.

20.

Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling.

Calvino C, Império GE, Wilieman M, Costa-E-Sousa RH, Souza LL, Trevenzoli IH, Pazos-Moura CC.

Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.

PMID:
26538454

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