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Structural diversity of G protein-coupled receptors and significance for drug discovery.

Lagerström MC, Schiöth HB. Lagerström MC, et al. Nat Rev Drug Discov. 2008 Apr;7(4):339-57. doi: 10.1038/nrd2518. Nat Rev Drug Discov. 2008. PMID: 18382464 Review.

The G protein-coupled receptor subset of the rat genome.

Gloriam DE, Fredriksson R, Schiöth HB. Gloriam DE, et al. BMC Genomics. 2007 Sep 25;8:338. doi: 10.1186/1471-2164-8-338. BMC Genomics. 2007. PMID: 17892602 Free PMC article.

Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.

Huber T, Menon S, Sakmar TP. Huber T, et al. Biochemistry. 2008 Oct 21;47(42):11013-23. doi: 10.1021/bi800891r. Epub 2008 Sep 27. Biochemistry. 2008. PMID: 18821775

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

Fredriksson R, Lagerström MC, Lundin LG, Schiöth HB. Fredriksson R, et al. Mol Pharmacol. 2003 Jun;63(6):1256-72. doi: 10.1124/mol.63.6.1256. Mol Pharmacol. 2003. PMID: 12761335

G-protein-coupled receptor heterodimerization: assay technologies to clinical significance.

Kent T, McAlpine C, Sabetnia S, Presland J. Kent T, et al. Curr Opin Drug Discov Devel. 2007 Sep;10(5):580-9. Curr Opin Drug Discov Devel. 2007. PMID: 17786857 Review.

Drug design strategies for targeting G-protein-coupled receptors.

Klabunde T, Hessler G. Klabunde T, et al. Chembiochem. 2002 Oct 4;3(10):928-44. doi: 10.1002/1439-7633(20021004)3:10<928::AID-CBIC928>3.0.CO;2-5. Chembiochem. 2002. PMID: 12362358 Review.

Prediction of G-protein-coupled receptor classes.

Chou KC. Chou KC. J Proteome Res. 2005 Jul-Aug;4(4):1413-8. doi: 10.1021/pr050087t. J Proteome Res. 2005. PMID: 16083294

The structure and dynamics of GPCR oligomers: a new focus in models of cell-signaling mechanisms and drug design.

Filizola M, Weinstein H. Filizola M, et al. Curr Opin Drug Discov Devel. 2005 Sep;8(5):577-84. Curr Opin Drug Discov Devel. 2005. PMID: 16159019 Review.

Modeling small molecule-compound binding to G-protein-coupled receptors.

Vaidehi N, Pease JE, Horuk R. Vaidehi N, et al. Methods Enzymol. 2009;460:263-88. doi: 10.1016/S0076-6879(09)05213-6. Methods Enzymol. 2009. PMID: 19446730

Informed development of drugs acting at family B G protein-coupled receptors.

Miller LJ. Miller LJ. Ann N Y Acad Sci. 2008 Nov;1144:203-9. doi: 10.1196/annals.1418.001. Ann N Y Acad Sci. 2008. PMID: 19076378

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