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Items: 1 to 20 of 130

1.

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ.

Nature. 2008 Mar 20;452(7185):370-4. doi: 10.1038/nature06780.

2.

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

Guardavaccaro D, Frescas D, Dorrello NV, Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A, Chang S, Hernando E, Pagano M.

Nature. 2008 Mar 20;452(7185):365-9. doi: 10.1038/nature06641.

3.

Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCF(β-TRCP) in neuroblastoma cells.

Singh A, Rokes C, Gireud M, Fletcher S, Baumgartner J, Fuller G, Stewart J, Zage P, Gopalakrishnan V.

Cancer. 2011 Nov 15;117(22):5189-202. doi: 10.1002/cncr.26145. Epub 2011 Apr 26.

4.

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4419-24. Epub 2004 Mar 22.

5.

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

Su Y, Fu C, Ishikawa S, Stella A, Kojima M, Shitoh K, Schreiber EM, Day BW, Liu B.

Mol Cell. 2008 Dec 5;32(5):652-61. doi: 10.1016/j.molcel.2008.10.023.

6.

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.

Genes Dev. 1999 Feb 1;13(3):270-83. Erratum in: Genes Dev 1999 Apr 15;13(8):1050.

7.

Ubiquitin E3 ligase SCF(β-TRCP) regulates TRIB2 stability in liver cancer cells.

Qiao Y, Zhang Y, Wang J.

Biochem Biophys Res Commun. 2013 Nov 22;441(3):555-9. doi: 10.1016/j.bbrc.2013.10.123. Epub 2013 Nov 5.

PMID:
24211582
8.

LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1).

Zou C, Butler PL, Coon TA, Smith RM, Hammen G, Zhao Y, Chen BB, Mallampalli RK.

J Biol Chem. 2011 Jan 28;286(4):2719-27. doi: 10.1074/jbc.M110.192377. Epub 2010 Nov 10.

9.

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.

Peschiaroli A, Skaar JR, Pagano M, Melino G.

Oncogene. 2010 Mar 4;29(9):1384-93. doi: 10.1038/onc.2009.430. Epub 2009 Dec 7.

10.

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

Shirogane T, Jin J, Ang XL, Harper JW.

J Biol Chem. 2005 Jul 22;280(29):26863-72. Epub 2005 May 24.

11.

The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.

Isoda M, Kanemori Y, Nakajo N, Uchida S, Yamashita K, Ueno H, Sagata N.

Mol Biol Cell. 2009 Apr;20(8):2186-95. doi: 10.1091/mbc.E09-01-0008. Epub 2009 Feb 25.

12.

The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor.

van Kerkhof P, Putters J, Strous GJ.

J Biol Chem. 2007 Jul 13;282(28):20475-83. Epub 2007 May 10. Erratum in: J Biol Chem. 2008 Apr 25;283(17):11860.

13.

SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.

Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM.

J Cell Sci. 2015 Mar 15;128(6):1123-38. doi: 10.1242/jcs.162164. Epub 2015 Jan 27.

14.
15.

Putative E3 ubiquitin ligase of human rotavirus inhibits NF-κB activation by using molecular mimicry to target β-TrCP.

Morelli M, Dennis AF, Patton JT.

MBio. 2015 Jan 27;6(1). pii: e02490-14. doi: 10.1128/mBio.02490-14.

16.

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.

Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, Bao S.

Nat Cell Biol. 2011 Feb;13(2):142-52. doi: 10.1038/ncb2153. Epub 2011 Jan 23.

17.

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.

Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H.

Mol Cell Biol. 2005 Apr;25(8):3338-47.

18.

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.

Coyaud E, Mis M, Laurent EM, Dunham WH, Couzens AL, Robitaille M, Gingras AC, Angers S, Raught B.

Mol Cell Proteomics. 2015 Jul;14(7):1781-95. doi: 10.1074/mcp.M114.045658. Epub 2015 Apr 21.

19.

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.

Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W.

Oncotarget. 2014 Feb 28;5(4):1026-37.

20.

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.

Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y.

Neoplasia. 2006 Dec;8(12):1042-54.

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