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Items: 1 to 20 of 714

1.

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D.

Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879.

PMID:
18354394
2.

Evolutionary optimization of computationally designed enzymes: Kemp eliminases of the KE07 series.

Khersonsky O, Röthlisberger D, Dym O, Albeck S, Jackson CJ, Baker D, Tawfik DS.

J Mol Biol. 2010 Mar 5;396(4):1025-42. doi: 10.1016/j.jmb.2009.12.031.

PMID:
20036254
3.

Computational biochemistry: old enzymes, new tricks.

Ghirlanda G.

Nature. 2008 May 8;453(7192):164-6. doi: 10.1038/453164a. No abstract available.

PMID:
18464727
4.

New algorithms and an in silico benchmark for computational enzyme design.

Zanghellini A, Jiang L, Wollacott AM, Cheng G, Meiler J, Althoff EA, Röthlisberger D, Baker D.

Protein Sci. 2006 Dec;15(12):2785-94.

5.

Engineered enzymes for improved organic synthesis.

Hult K, Berglund P.

Curr Opin Biotechnol. 2003 Aug;14(4):395-400. Review.

PMID:
12943848
6.

Computational design of a biologically active enzyme.

Dwyer MA, Looger LL, Hellinga HW.

Science. 2004 Jun 25;304(5679):1967-71. Retraction in: Dwyer MA, Looger LL, Hellinga HW. Science. 2008 Feb 1;319(5863):569.

7.

Design of protein catalysts.

Hilvert D.

Annu Rev Biochem. 2013;82:447-70. doi: 10.1146/annurev-biochem-072611-101825. Review.

PMID:
23746259
8.

Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59.

Khersonsky O, Kiss G, Röthlisberger D, Dym O, Albeck S, Houk KN, Baker D, Tawfik DS.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10358-63. doi: 10.1073/pnas.1121063109.

9.

Enantioselective biocatalysis optimized by directed evolution.

Jaeger KE, Eggert T.

Curr Opin Biotechnol. 2004 Aug;15(4):305-13. Review.

PMID:
15358000
10.

Novel methods for directed evolution of enzymes: quality, not quantity.

Lutz S, Patrick WM.

Curr Opin Biotechnol. 2004 Aug;15(4):291-7. Review.

PMID:
15296927
11.

Enzyme-like proteins from an unselected library of designed amino acid sequences.

Wei Y, Hecht MH.

Protein Eng Des Sel. 2004 Jan;17(1):67-75.

PMID:
14985539
12.

Novel concepts for selection of catalytic activity.

Soumillion P, Fastrez J.

Curr Opin Biotechnol. 2001 Aug;12(4):387-94. Review.

PMID:
11551468
13.

De novo enzymes by computational design.

Kries H, Blomberg R, Hilvert D.

Curr Opin Chem Biol. 2013 Apr;17(2):221-8. doi: 10.1016/j.cbpa.2013.02.012. Review.

PMID:
23498973
14.

Computational enzymology: insight into biological catalysts from modelling.

van der Kamp MW, Mulholland AJ.

Nat Prod Rep. 2008 Dec;25(6):1001-14. doi: 10.1039/b600517a. Review.

PMID:
19030602
15.

Milestones in directed enzyme evolution.

Tao H, Cornish VW.

Curr Opin Chem Biol. 2002 Dec;6(6):858-64. Review.

PMID:
12470742
16.

Directed evolution of enzymes and pathways for industrial biocatalysis.

Zhao H, Chockalingam K, Chen Z.

Curr Opin Biotechnol. 2002 Apr;13(2):104-10. Review.

PMID:
11950559
17.

Improved biocatalysts by directed evolution and rational protein design.

Bornscheuer UT, Pohl M.

Curr Opin Chem Biol. 2001 Apr;5(2):137-43. Review.

PMID:
11282339
18.

Precision is essential for efficient catalysis in an evolved Kemp eliminase.

Blomberg R, Kries H, Pinkas DM, Mittl PR, Grütter MG, Privett HK, Mayo SL, Hilvert D.

Nature. 2013 Nov 21;503(7476):418-21. doi: 10.1038/nature12623.

PMID:
24132235
19.

Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26.

Kmunícek J, Hynková K, Jedlicka T, Nagata Y, Negri A, Gago F, Wade RC, Damborský J.

Biochemistry. 2005 Mar 8;44(9):3390-401.

PMID:
15736949
20.

Minimalist active-site redesign: teaching old enzymes new tricks.

Toscano MD, Woycechowsky KJ, Hilvert D.

Angew Chem Int Ed Engl. 2007;46(18):3212-36. Review.

PMID:
17450624

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