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Items: 1 to 20 of 79

1.

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.

Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M.

J Cell Sci. 2008 Apr 1;121(Pt 7):979-88. doi: 10.1242/jcs.009530.

2.

Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

Lents NH, Keenan SM, Bellone C, Baldassare JJ.

J Biol Chem. 2002 Dec 6;277(49):47469-75. Epub 2002 Sep 30.

3.

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.

Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9.

4.

CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner.

Yoshida A, Yoneda-Kato N, Kato JY.

Sci Rep. 2013;3:1054. doi: 10.1038/srep01054. Epub 2013 Jan 11.

5.

Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.

Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M.

Mol Cell Biol. 2009 Mar;29(5):1235-48. doi: 10.1128/MCB.00668-08. Epub 2008 Dec 22.

6.

Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.

Chen KC, Yang TY, Wu CC, Cheng CC, Hsu SL, Hung HW, Chen JW, Chang GC.

PLoS One. 2014 May 21;9(5):e97888. doi: 10.1371/journal.pone.0097888. eCollection 2014.

7.
8.

Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.

Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B.

Oncogene. 2010 Jan 21;29(3):345-55. doi: 10.1038/onc.2009.329. Epub 2009 Oct 19.

PMID:
19838216
9.

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

Gu Y, Rosenblatt J, Morgan DO.

EMBO J. 1992 Nov;11(11):3995-4005.

11.

Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.

Peng C, Zeng W, Su J, Kuang Y, He Y, Zhao S, Zhang J, Ma W, Bode AM, Dong Z, Chen X.

Oncogene. 2016 Mar 3;35(9):1170-9. doi: 10.1038/onc.2015.175. Epub 2015 Jun 1.

12.

Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome.

Villavicencio A, Goyeneche A, Telleria C, Bacallao K, Gabler F, Fuentes A, Vega M.

Gynecol Oncol. 2009 Oct;115(1):102-7. doi: 10.1016/j.ygyno.2009.06.033. Epub 2009 Jul 23.

13.

Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.

Oakes V, Wang W, Harrington B, Lee WJ, Beamish H, Chia KM, Pinder A, Goto H, Inagaki M, Pavey S, Gabrielli B.

Cell Cycle. 2014;13(20):3302-11. doi: 10.4161/15384101.2014.949111.

14.
15.

Phospholipase C delta 1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E-CDK2 activity.

Kaproth-Joslin KA, Li X, Reks SE, Kelley GG.

Biochem J. 2008 Nov 1;415(3):439-48. doi: 10.1042/BJ20080233.

PMID:
18588506
16.
17.

Functional interactions between herpesvirus oncoprotein MEQ and cell cycle regulator CDK2.

Liu JL, Ye Y, Qian Z, Qian Y, Templeton DJ, Lee LF, Kung HJ.

J Virol. 1999 May;73(5):4208-19.

18.

Cyclin E-CDK2 is a regulator of p27Kip1.

Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE.

Genes Dev. 1997 Jun 1;11(11):1464-78.

20.

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