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Items: 1 to 20 of 76

1.

Variations in DNA elucidate molecular networks that cause disease.

Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE.

Nature. 2008 Mar 27;452(7186):429-35. doi: 10.1038/nature06757. Epub 2008 Mar 16.

2.

Cis-regulatory variations: a study of SNPs around genes showing cis-linkage in segregating mouse populations.

GuhaThakurta D, Xie T, Anand M, Edwards SW, Li G, Wang SS, Schadt EE.

BMC Genomics. 2006 Sep 15;7:235.

3.

Mapping the genetic architecture of gene expression in human liver.

Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R.

PLoS Biol. 2008 May 6;6(5):e107. doi: 10.1371/journal.pbio.0060107.

4.

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA.

Nat Genet. 2009 Apr;41(4):415-23. doi: 10.1038/ng.325. Epub 2009 Mar 8.

5.

Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.

Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE.

Nat Genet. 2005 Nov;37(11):1224-33. Epub 2005 Oct 2. Erratum in: Nat Genet. 2005 Dec;37(12):1381.

PMID:
16200066
6.

An integrative genomics approach to infer causal associations between gene expression and disease.

Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ.

Nat Genet. 2005 Jul;37(7):710-7. Epub 2005 Jun 19.

7.

Moving toward a system genetics view of disease.

Sieberts SK, Schadt EE.

Mamm Genome. 2007 Jul;18(6-7):389-401. Epub 2007 Jul 26. Review.

8.

Relationship between obesity phenotypes and genetic determinants in a mouse model for juvenile obesity.

Brockmann GA, Schäfer N, Hesse C, Heise S, Neuschl C, Wagener A, Churchill GA, Li R.

Physiol Genomics. 2013 Sep 16;45(18):817-26. doi: 10.1152/physiolgenomics.00058.2013. Epub 2013 Aug 6.

PMID:
23922126
9.

Uncovering the genetic landscape for multiple sleep-wake traits.

Winrow CJ, Williams DL, Kasarskis A, Millstein J, Laposky AD, Yang HS, Mrazek K, Zhou L, Owens JR, Radzicki D, Preuss F, Schadt EE, Shimomura K, Vitaterna MH, Zhang C, Koblan KS, Renger JJ, Turek FW.

PLoS One. 2009;4(4):e5161. doi: 10.1371/journal.pone.0005161. Epub 2009 Apr 10.

10.

Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.

Farber CR, Aten JE, Farber EA, de Vera V, Gularte R, Islas-Trejo A, Wen P, Horvath S, Lucero M, Lusis AJ, Medrano JF.

Physiol Genomics. 2009 May 13;37(3):294-302. doi: 10.1152/physiolgenomics.90245.2008. Epub 2009 Mar 31.

11.

Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver.

Musso G, Paschetta E, Gambino R, Cassader M, Molinaro F.

Trends Mol Med. 2013 Sep;19(9):522-35. doi: 10.1016/j.molmed.2013.05.006. Epub 2013 Jun 28. Review.

12.

Effects of lipoprotein lipase and peroxisome proliferator-activated receptor-gamma gene variants on metabolic syndrome traits.

Bozina T, Simić I, Lovrić J, Pećin I, Jelaković B, Sertić J, Reiner Z.

Coll Antropol. 2013 Sep;37(3):801-8.

PMID:
24308220
13.

Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study.

Kraja AT, Hunt SC, Pankow JS, Myers RH, Heiss G, Lewis CE, Rao DC, Province MA.

Obes Res. 2005 Nov;13(11):1885-90.

14.

Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program.

Kraja AT, Rao DC, Weder AB, Cooper R, Curb JD, Hanis CL, Turner ST, de Andrade M, Hsiung CA, Quertermous T, Zhu X, Province MA.

Hypertension. 2005 Oct;46(4):751-7. Epub 2005 Sep 19.

15.

Genomic analysis of metabolic pathway gene expression in mice.

Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis AJ, Drake TA.

Genome Biol. 2005;6(7):R59. Epub 2005 Jul 1.

16.

Genetics of gene expression surveyed in maize, mouse and man.

Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH.

Nature. 2003 Mar 20;422(6929):297-302.

PMID:
12646919
17.

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.

Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG; Cardiogenics Consortium, Erdmann J, Hengstenberg C, Maouche S, Ouwehand WH, Rice CM, Samani NJ, Schunkert H, Goodall AH, Schulz H, Roider HG, Vingron M, Blankenberg S, Münzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth DJ, Pravenec M, Aitman TJ, Cambien F, Clayton D, Todd JA, Hubner N, Cook SA.

Nature. 2010 Sep 23;467(7314):460-4. doi: 10.1038/nature09386. Epub 2010 Sep 8.

18.
19.

Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression.

Kirchgessner TG, LeBoeuf RC, Langner CA, Zollman S, Chang CH, Taylor BA, Schotz MC, Gordon JI, Lusis AJ.

J Biol Chem. 1989 Jan 25;264(3):1473-82.

20.

Genetics of gene expression and its effect on disease.

Emilsson V, Thorleifsson G, Zhang B, Leonardson AS, Zink F, Zhu J, Carlson S, Helgason A, Walters GB, Gunnarsdottir S, Mouy M, Steinthorsdottir V, Eiriksdottir GH, Bjornsdottir G, Reynisdottir I, Gudbjartsson D, Helgadottir A, Jonasdottir A, Jonasdottir A, Styrkarsdottir U, Gretarsdottir S, Magnusson KP, Stefansson H, Fossdal R, Kristjansson K, Gislason HG, Stefansson T, Leifsson BG, Thorsteinsdottir U, Lamb JR, Gulcher JR, Reitman ML, Kong A, Schadt EE, Stefansson K.

Nature. 2008 Mar 27;452(7186):423-8. doi: 10.1038/nature06758. Epub 2008 Mar 16.

PMID:
18344981

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