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Items: 1 to 20 of 289

1.

CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.

He X, Park K, Wang H, He X, Zhang Y, Hua X, Li Y, Kappes DJ.

Immunity. 2008 Mar;28(3):346-58. doi: 10.1016/j.immuni.2008.02.006.

2.

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.

Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, Taniuchi I.

Nat Immunol. 2008 Oct;9(10):1113-21. doi: 10.1038/ni.1650. Epub 2008 Sep 7.

PMID:
18776907
4.

Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes.

van Hamburg JP, de Bruijn MJ, Ribeiro de Almeida C, Dingjan GM, Hendriks RW.

Mol Immunol. 2009 Oct;46(16):3251-60. doi: 10.1016/j.molimm.2009.08.004. Epub 2009 Sep 2.

PMID:
19729201
5.

CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision.

Yin X, Ladi E, Chan SW, Li O, Killeen N, Kappes DJ, Robey EA.

J Immunol. 2007 Dec 1;179(11):7358-64.

6.

Overexpression of the Runx3 transcription factor increases the proportion of mature thymocytes of the CD8 single-positive lineage.

Kohu K, Sato T, Ohno S, Hayashi K, Uchino R, Abe N, Nakazato M, Yoshida N, Kikuchi T, Iwakura Y, Inoue Y, Watanabe T, Habu S, Satake M.

J Immunol. 2005 Mar 1;174(5):2627-36.

7.

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells.

Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Möröy T, Taniuchi I, Steimle V, Littman DR, Ehlers M.

J Immunol. 2005 Aug 1;175(3):1694-705. Erratum in: J Immunol. 2005 Nov 1;175(9):6238.

8.

Early growth response (Egr)-1 gene induction in the thymus in response to TCR ligation during early steps in positive selection is not required for CD8 lineage commitment.

Basson MA, Wilson TJ, Legname GA, Sarner N, Tomlinson PD, Tybulewicz VL, Zamoyska R.

J Immunol. 2000 Sep 1;165(5):2444-50.

9.

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate.

Yasutomo K, Doyle C, Miele L, Fuchs C, Germain RN.

Nature. 2000 Mar 30;404(6777):506-10. Erratum in: Nature 2000 Sep 7;407(6800):110.

PMID:
10761920
10.

Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes.

Egawa T, Taniuchi I.

Blood Cells Mol Dis. 2009 Jul-Aug;43(1):27-9. doi: 10.1016/j.bcmd.2009.03.004. Epub 2009 Apr 16.

PMID:
19375362
12.

Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.

Izon DJ, Punt JA, Xu L, Karnell FG, Allman D, Myung PS, Boerth NJ, Pui JC, Koretzky GA, Pear WS.

Immunity. 2001 Mar;14(3):253-64.

13.

Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.

Muroi S, Tanaka H, Miyamoto C, Taniuchi I.

J Immunol. 2013 Feb 15;190(4):1397-401. doi: 10.4049/jimmunol.1203006. Epub 2013 Jan 11.

14.

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.

He X, He X, Dave VP, Zhang Y, Hua X, Nicolas E, Xu W, Roe BA, Kappes DJ.

Nature. 2005 Feb 24;433(7028):826-33.

15.

Thymocyte-intrinsic genetic factors influence CD8 T cell lineage commitment and affect selection of a tumor-reactive TCR.

Shanker A, Auphan-Anezin N, Chomez P, Giraudo L, Van den Eynde B, Schmitt-Verhulst AM.

J Immunol. 2004 Apr 15;172(8):5069-77.

16.
17.

p300-mediated acetylation stabilizes the Th-inducing POK factor.

Zhang M, Zhang J, Rui J, Liu X.

J Immunol. 2010 Oct 1;185(7):3960-9. doi: 10.4049/jimmunol.1001462. Epub 2010 Sep 1.

18.

Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.

Sato T, Ohno S, Hayashi T, Sato C, Kohu K, Satake M, Habu S.

Immunity. 2005 Mar;22(3):317-28.

19.

RasGRP1 transmits prodifferentiation TCR signaling that is crucial for CD4 T cell development.

Priatel JJ, Chen X, Dhanji S, Abraham N, Teh HS.

J Immunol. 2006 Aug 1;177(3):1470-80.

20.

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