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Items: 1 to 20 of 162

1.

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.

Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY.

Blood. 2008 May 15;111(10):5195-204. doi: 10.1182/blood-2007-09-111567. Epub 2008 Mar 7.

2.

Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver.

Zhao N, Maxson JE, Zhang RH, Wahedi M, Enns CA, Zhang AS.

J Biol Chem. 2016 Jun 3;291(23):12322-35. doi: 10.1074/jbc.M116.721191. Epub 2016 Apr 12.

3.

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.

Zhang AS, Anderson SA, Meyers KR, Hernandez C, Eisenstein RS, Enns CA.

J Biol Chem. 2007 Apr 27;282(17):12547-56. Epub 2007 Mar 1.

4.

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression.

Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA.

J Biol Chem. 2009 Aug 21;284(34):22580-9. doi: 10.1074/jbc.M109.027318. Epub 2009 Jun 29.

5.

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.

Lee DH, Zhou LJ, Zhou Z, Xie JX, Jung JU, Liu Y, Xi CX, Mei L, Xiong WC.

Blood. 2010 Apr 15;115(15):3136-45. doi: 10.1182/blood-2009-11-251199. Epub 2010 Jan 11. Erratum in: Blood. 2010 Jul 8;116(1):151. Lee, Dai-Hoon [corrected to Lee, Dae-Hoon]; Zhou, Li-Juau [corrected to Zhou, Li-Juan]; Xie, Jiau-Xiu [corrected to Xie, Jian-Xin].

6.

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.

Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY.

J Biol Chem. 2007 Jun 22;282(25):18129-40. Epub 2007 May 1.

7.

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY.

Nat Genet. 2006 May;38(5):531-9. Epub 2006 Apr 9.

PMID:
16604073
8.

BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG.

PLoS One. 2011 Jan 21;6(1):e14553. doi: 10.1371/journal.pone.0014553.

9.

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD.

Casanovas G, Mleczko-Sanecka K, Altamura S, Hentze MW, Muckenthaler MU.

J Mol Med (Berl). 2009 May;87(5):471-80. doi: 10.1007/s00109-009-0447-2. Epub 2009 Feb 20.

PMID:
19229506
10.

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane.

Zhang AS, Yang F, Meyer K, Hernandez C, Chapman-Arvedson T, Bjorkman PJ, Enns CA.

J Biol Chem. 2008 Jun 20;283(25):17494-502. doi: 10.1074/jbc.M710527200. Epub 2008 Apr 29.

11.

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.

Steinbicker AU, Bartnikas TB, Lohmeyer LK, Leyton P, Mayeur C, Kao SM, Pappas AE, Peterson RT, Bloch DB, Yu PB, Fleming MD, Bloch KD.

Blood. 2011 Oct 13;118(15):4224-30. doi: 10.1182/blood-2011-03-339952. Epub 2011 Aug 12.

12.

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.

Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY.

J Clin Invest. 2007 Jul;117(7):1933-9.

13.

Neogenin interacts with hemojuvelin through its two membrane-proximal fibronectin type III domains.

Yang F, West AP Jr, Allendorph GP, Choe S, Bjorkman PJ.

Biochemistry. 2008 Apr 8;47(14):4237-45. doi: 10.1021/bi800036h. Epub 2008 Mar 13.

14.

Hepcidin regulation: ironing out the details.

De Domenico I, Ward DM, Kaplan J.

J Clin Invest. 2007 Jul;117(7):1755-8.

15.
16.

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.

Kuns-Hashimoto R, Kuninger D, Nili M, Rotwein P.

Am J Physiol Cell Physiol. 2008 Apr;294(4):C994-C1003. doi: 10.1152/ajpcell.00563.2007. Epub 2008 Feb 20.

17.

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.

Silvestri L, Pagani A, Camaschella C.

Blood. 2008 Jan 15;111(2):924-31. Epub 2007 Oct 15.

18.

Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal Angiogenesis.

Lee HW, Chong DC, Ola R, Dunworth WP, Meadows S, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A, Jin SW.

Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):657-663. doi: 10.1161/ATVBAHA.116.308422. Epub 2017 Feb 23.

PMID:
28232325
19.

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.

Truksa J, Peng H, Lee P, Beutler E.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10289-93. Epub 2006 Jun 26.

20.

MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.

Zumbrennen-Bullough KB, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL.

J Biol Chem. 2014 Aug 22;289(34):23796-808. doi: 10.1074/jbc.M114.577387. Epub 2014 Jul 7.

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