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Small molecule activator of the human epithelial sodium channel.

Lu M, Echeverri F, Kalabat D, Laita B, Dahan DS, Smith RD, Xu H, Staszewski L, Yamamoto J, Ling J, Hwang N, Kimmich R, Li P, Patron E, Keung W, Patron A, Moyer BD.

J Biol Chem. 2008 May 2;283(18):11981-94. doi: 10.1074/jbc.M708001200. Epub 2008 Mar 6.


The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.

Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR.

J Biol Chem. 2006 Jul 7;281(27):18901-7. Epub 2006 May 11.


A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.

Gründer S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP, Rossier BC.

EMBO J. 1997 Mar 3;16(5):899-907.


The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.

Haerteis S, Krueger B, Korbmacher C, Rauh R.

J Biol Chem. 2009 Oct 16;284(42):29024-40. doi: 10.1074/jbc.M109.018945. Epub 2009 Aug 28.


Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis.

Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, Rossier BC.

J Biol Chem. 2008 Mar 21;283(12):7455-63. doi: 10.1074/jbc.M707399200. Epub 2008 Jan 14.


Charged residues in the M2 region of alpha-hENaC play a role in channel conductance.

Langloh AL, Berdiev B, Ji HL, Keyser K, Stanton BA, Benos DJ.

Am J Physiol Cell Physiol. 2000 Feb;278(2):C277-91.


Liddle-Mutation of the β-Subunit, but not the γ-Subunit, Attenuates Protein Kinase C-Mediated Inhibition of Human Epithelial Sodium Channels (hENaC).

Robins GG, Sandle GI.

J Membr Biol. 2016 Jun;249(3):271-9. doi: 10.1007/s00232-015-9866-x. Epub 2016 Jan 12.


Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.

Shi S, Kleyman TR.

Am J Physiol Renal Physiol. 2013 Dec 1;305(11):F1585-92. doi: 10.1152/ajprenal.00337.2013. Epub 2013 Oct 9.


Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel.

Ji HL, Benos DJ.

J Biol Chem. 2004 Jun 25;279(26):26939-47. Epub 2004 Apr 14.


Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.

Sheng S, Carattino MD, Bruns JB, Hughey RP, Kleyman TR.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1488-96. Epub 2006 Jan 31.


Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.

Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, Kleyman TR.

J Biol Chem. 2007 Mar 2;282(9):6153-60. Epub 2007 Jan 1.


Cleavage in the {gamma}-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels.

Diakov A, Bera K, Mokrushina M, Krueger B, Korbmacher C.

J Physiol. 2008 Oct 1;586(19):4587-608. doi: 10.1113/jphysiol.2008.154435. Epub 2008 Jul 31.


ENaC proteolytic regulation by channel-activating protease 2.

García-Caballero A, Dang Y, He H, Stutts MJ.

J Gen Physiol. 2008 Nov;132(5):521-35. doi: 10.1085/jgp.200810030. Epub 2008 Oct 13.


A new subunit of the epithelial Na+ channel identifies regions involved in Na+ self-inhibition.

Babini E, Geisler HS, Siba M, Gründer S.

J Biol Chem. 2003 Aug 1;278(31):28418-26. Epub 2003 May 21.


Voltage-dependent gating underlies loss of ENaC function in Pseudohypoaldosteronism type 1.

Kucher V, Boiko N, Pochynyuk O, Stockand JD.

Biophys J. 2011 Apr 20;100(8):1930-9. doi: 10.1016/j.bpj.2011.02.046.


Activation of the epithelial sodium channel by the metalloprotease meprin β subunit.

Garcia-Caballero A, Ishmael SS, Dang Y, Gillie D, Bond JS, Milgram SL, Stutts MJ.

Channels (Austin). 2011 Jan-Feb;5(1):14-22. Epub 2011 Jan 1.


Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo.

Lazrak A, Nita I, Subramaniyam D, Wei S, Song W, Ji HL, Janciauskiene S, Matalon S.

Am J Respir Cell Mol Biol. 2009 Sep;41(3):261-70. doi: 10.1165/rcmb.2008-0384OC. Epub 2009 Jan 8.


Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.

Renauld S, Allache R, Chraibi C.

Cell Physiol Biochem. 2008;22(1-4):101-8. doi: 10.1159/000149787. Epub 2008 Jul 25.


Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the γ subunit of the human epithelial sodium channel.

Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C.

J Gen Physiol. 2012 Oct;140(4):375-89. Epub 2012 Sep 10.


Cysteine palmitoylation of the γ subunit has a dominant role in modulating activity of the epithelial sodium channel.

Mukherjee A, Mueller GM, Kinlough CL, Sheng N, Wang Z, Mustafa SA, Kashlan OB, Kleyman TR, Hughey RP.

J Biol Chem. 2014 May 16;289(20):14351-9. doi: 10.1074/jbc.M113.526020. Epub 2014 Apr 1.

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