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Items: 1 to 20 of 128

1.

Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V.

Cell Signal. 2008 Jun;20(6):1084-91. doi: 10.1016/j.cellsig.2008.01.020. Epub 2008 Feb 1.

2.

Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.

Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V.

J Biol Chem. 2004 Jan 9;279(2):1351-8. Epub 2003 Oct 14.

3.
4.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.

5.

Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM.

Maeurer C, Holland S, Pierre S, Potstada W, Scholich K.

Cell Signal. 2009 Feb;21(2):293-300. doi: 10.1016/j.cellsig.2008.10.016. Epub 2008 Oct 30.

PMID:
19000755
6.

The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.

Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V.

J Biol Chem. 2012 Aug 31;287(36):30063-72. doi: 10.1074/jbc.M112.353987. Epub 2012 Jul 13.

7.

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6. Epub 2002 Sep 23.

8.

Tumour suppressors hamartin and tuberin: intracellular signalling.

Krymskaya VP.

Cell Signal. 2003 Aug;15(8):729-39. Review.

PMID:
12781866
9.

Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex.

Nellist M, Sancak O, Goedbloed MA, Rohe C, van Netten D, Mayer K, Tucker-Williams A, van den Ouweland AM, Halley DJ.

Eur J Hum Genet. 2005 Jan;13(1):59-68.

11.

Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell model.

Mi R, Ma J, Zhang D, Li L, Zhang H.

J Genet Genomics. 2009 Jun;36(6):355-61. doi: 10.1016/S1673-8527(08)60124-1.

PMID:
19539245
12.

Missense mutations to the TSC1 gene cause tuberous sclerosis complex.

Nellist M, van den Heuvel D, Schluep D, Exalto C, Goedbloed M, Maat-Kievit A, van Essen T, van Spaendonck-Zwarts K, Jansen F, Helderman P, Bartalini G, Vierimaa O, Penttinen M, van den Ende J, van den Ouweland A, Halley D.

Eur J Hum Genet. 2009 Mar;17(3):319-28. doi: 10.1038/ejhg.2008.170. Epub 2008 Oct 1.

13.

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.

Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R.

J Cell Biol. 2002 Oct 28;159(2):217-24. Epub 2002 Oct 28.

14.

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D.

J Biol Chem. 2016 Sep 16;291(38):20008-20. doi: 10.1074/jbc.M116.732446. Epub 2016 Aug 4.

15.

TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

Chong-Kopera H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo FR, Rosa JL, Guan KL.

J Biol Chem. 2006 Mar 31;281(13):8313-6. Epub 2006 Feb 7.

16.

Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer.

Fuchs A, König K, Heukamp LC, Fassunke J, Kirfel J, Huss S, Becker AJ, Büttner R, Majores M.

Diagn Pathol. 2014 Mar 4;9:48. doi: 10.1186/1746-1596-9-48.

17.

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners.

Rosner M, Hanneder M, Siegel N, Valli A, Hengstschläger M.

Mutat Res. 2008 Mar-Apr;658(3):234-46. doi: 10.1016/j.mrrev.2008.01.001. Epub 2008 Jan 12. Review.

PMID:
18291711
18.

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.

Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, Broaddus RR, Walker CL.

Clin Cancer Res. 2008 May 1;14(9):2543-50. doi: 10.1158/1078-0432.CCR-07-0321.

19.

Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients.

Habib SL.

Mol Cancer. 2009 Mar 5;8:13. doi: 10.1186/1476-4598-8-13.

20.

Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway.

Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O.

Int J Oncol. 2013 Aug;43(2):447-56. doi: 10.3892/ijo.2013.1984. Epub 2013 Jun 12.

PMID:
23759924

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