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Items: 1 to 20 of 112

1.

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.

Solowska JM, Morfini G, Falnikar A, Himes BT, Brady ST, Huang D, Baas PW.

J Neurosci. 2008 Feb 27;28(9):2147-57. doi: 10.1523/JNEUROSCI.3159-07.2008.

2.

Hereditary spastic paraplegia SPG4: what is known and not known about the disease.

Solowska JM, Baas PW.

Brain. 2015 Sep;138(Pt 9):2471-84. doi: 10.1093/brain/awv178. Epub 2015 Jun 20. Review.

3.

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia.

Solowska JM, Garbern JY, Baas PW.

Hum Mol Genet. 2010 Jul 15;19(14):2767-79. doi: 10.1093/hmg/ddq177. Epub 2010 Apr 29.

4.

Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.

Solowska JM, D'Rozario M, Jean DC, Davidson MW, Marenda DR, Baas PW.

J Neurosci. 2014 Jan 29;34(5):1856-67. doi: 10.1523/JNEUROSCI.3309-13.2014.

5.

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.

Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B.

Hum Mol Genet. 2014 May 15;23(10):2527-41. doi: 10.1093/hmg/ddt644. Epub 2013 Dec 30.

6.

Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.

Denton KR, Lei L, Grenier J, Rodionov V, Blackstone C, Li XJ.

Stem Cells. 2014 Feb;32(2):414-23. doi: 10.1002/stem.1569.

7.

The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.

Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ, Cunliffe VT.

Hum Mol Genet. 2006 Sep 15;15(18):2763-71. Epub 2006 Aug 7.

PMID:
16893913
8.

The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.

Yu W, Qiang L, Solowska JM, Karabay A, Korulu S, Baas PW.

Mol Biol Cell. 2008 Apr;19(4):1485-98. doi: 10.1091/mbc.E07-09-0878. Epub 2008 Jan 30.

9.

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.

Sherwood NT, Sun Q, Xue M, Zhang B, Zinn K.

PLoS Biol. 2004 Dec;2(12):e429. Epub 2004 Nov 30.

10.

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.

Kasher PR, De Vos KJ, Wharton SB, Manser C, Bennett EJ, Bingley M, Wood JD, Milner R, McDermott CJ, Miller CC, Shaw PJ, Grierson AJ.

J Neurochem. 2009 Jul;110(1):34-44. doi: 10.1111/j.1471-4159.2009.06104.x. Epub 2009 Apr 22.

11.

Pleiotropic effects of spastin on neurite growth depending on expression levels.

Riano E, Martignoni M, Mancuso G, Cartelli D, Crippa F, Toldo I, Siciliano G, Di Bella D, Taroni F, Bassi MT, Cappelletti G, Rugarli EI.

J Neurochem. 2009 Mar;108(5):1277-88. doi: 10.1111/j.1471-4159.2009.05875.x. Epub 2009 Jan 29.

12.
13.

Spastin and microtubules: Functions in health and disease.

Salinas S, Carazo-Salas RE, Proukakis C, Schiavo G, Warner TT.

J Neurosci Res. 2007 Sep;85(12):2778-82. Review.

PMID:
17348041
14.

Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network.

Park SH, Zhu PP, Parker RL, Blackstone C.

J Clin Invest. 2010 Apr;120(4):1097-110. doi: 10.1172/JCI40979.

15.

Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus.

Charvin D, Cifuentes-Diaz C, Fonknechten N, Joshi V, Hazan J, Melki J, Betuing S.

Hum Mol Genet. 2003 Jan 1;12(1):71-8.

PMID:
12490534
16.

A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform.

Mancuso G, Rugarli EI.

BMC Biol. 2008 Jul 9;6:31. doi: 10.1186/1741-7007-6-31.

17.

Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.

Butler R, Wood JD, Landers JA, Cunliffe VT.

Dis Model Mech. 2010 Nov-Dec;3(11-12):743-51. doi: 10.1242/dmm.004002. Epub 2010 Sep 9.

18.

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.

Evans KJ, Gomes ER, Reisenweber SM, Gundersen GG, Lauring BP.

J Cell Biol. 2005 Feb 14;168(4):599-606.

19.

Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation.

McDermott CJ, Grierson AJ, Wood JD, Bingley M, Wharton SB, Bushby KM, Shaw PJ.

Ann Neurol. 2003 Dec;54(6):748-59.

PMID:
14681884
20.

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.

Fassier C, Tarrade A, Peris L, Courageot S, Mailly P, Dalard C, Delga S, Roblot N, Lefèvre J, Job D, Hazan J, Curmi PA, Melki J.

Dis Model Mech. 2013 Jan;6(1):72-83. doi: 10.1242/dmm.008946. Epub 2012 Jul 5.

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