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Items: 1 to 20 of 100

1.

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.

Ma Z, Sharp KA, Janmey PA, Finkel TH.

PLoS Biol. 2008 Feb;6(2):e43. doi: 10.1371/journal.pbio.0060043.

2.

The receptor deformation model of TCR triggering.

Ma Z, Janmey PA, Finkel TH.

FASEB J. 2008 Apr;22(4):1002-8. Epub 2007 Nov 5.

3.

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA.

Nature. 2005 Jul 28;436(7050):578-82.

PMID:
16049493
4.

T cell triggering: insights from 2D kinetics analysis of molecular interactions.

Zarnitsyna V, Zhu C.

Phys Biol. 2012 Aug;9(4):045005. doi: 10.1088/1478-3975/9/4/045005. Epub 2012 Aug 7. Review.

PMID:
22871794
5.

TCR triggering by the pMHC complex: valency, affinity, and dynamics.

Varma R.

Sci Signal. 2008 May 13;1(19):pe21. doi: 10.1126/stke.119pe21.

PMID:
18480017
6.

Insights from in situ analysis of TCR-pMHC recognition: response of an interaction network.

Zhu C, Jiang N, Huang J, Zarnitsyna VI, Evavold BD.

Immunol Rev. 2013 Jan;251(1):49-64. doi: 10.1111/imr.12016. Review.

7.

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

Manz BN, Jackson BL, Petit RS, Dustin ML, Groves J.

Proc Natl Acad Sci U S A. 2011 May 31;108(22):9089-94. doi: 10.1073/pnas.1018771108. Epub 2011 May 16.

8.

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay.

Axmann M, Sch├╝tz GJ, Huppa JB.

J Vis Exp. 2015 Oct 30;(105):e53157. doi: 10.3791/53157.

9.

TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length.

Ma Z, LeBard DN, Loverde SM, Sharp KA, Klein ML, Discher DE, Finkel TH.

PLoS One. 2014 Nov 10;9(11):e112292. doi: 10.1371/journal.pone.0112292. eCollection 2014.

10.

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.

Liu B, Chen W, Natarajan K, Li Z, Margulies DH, Zhu C.

Eur J Immunol. 2015 Jul;45(7):2099-110. doi: 10.1002/eji.201445358. Epub 2015 May 22.

11.

T cell receptor triggering by force.

Ma Z, Finkel TH.

Trends Immunol. 2010 Jan;31(1):1-6. doi: 10.1016/j.it.2009.09.008.

13.

Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.

Cai Z, Brunmark AB, Luxembourg AT, Garcia KC, Degano M, Teyton L, Wilson I, Peterson PA, Sprent J, Jackson MR.

Immunol Rev. 1998 Oct;165:249-65. Review.

PMID:
9850865
14.

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells.

O'Donoghue GP, Pielak RM, Smoligovets AA, Lin JJ, Groves JT.

Elife. 2013 Jul 3;2:e00778. doi: 10.7554/eLife.00778.

15.

Fate of intercellular MHC-peptide-T-cell receptor complexes during T-cell activation.

Clark BR.

J Mol Recognit. 1995 Jan-Apr;8(1-2):63-6. Review.

PMID:
7598954
16.

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA.

J Immunol. 2000 May 1;164(9):4433-42.

17.

T cell antigen recognition at the cell membrane.

Huang J, Meyer C, Zhu C.

Mol Immunol. 2012 Oct;52(3-4):155-64. doi: 10.1016/j.molimm.2012.05.004. Epub 2012 Jun 7. Review.

18.

Quantifying the strength of ligand antagonism in TCR triggering.

Van Den Berg HA, Burroughs NJ, Rand DA.

Bull Math Biol. 2002 Jul;64(4):781-808.

PMID:
12216421
19.
20.

Modeling T cell antigen discrimination based on feedback control of digital ERK responses.

Altan-Bonnet G, Germain RN.

PLoS Biol. 2005 Nov;3(11):e356. Epub 2005 Oct 25.

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