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Items: 1 to 20 of 93

1.

HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice.

Atkins KM, Thomas L, Youker RT, Harriff MJ, Pissani F, You H, Thomas G.

J Biol Chem. 2008 Apr 25;283(17):11772-84. doi: 10.1074/jbc.M707572200. Epub 2008 Feb 22.

2.

Small molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef action.

Dikeakos JD, Atkins KM, Thomas L, Emert-Sedlak L, Byeon IJ, Jung J, Ahn J, Wortman MD, Kukull B, Saito M, Koizumi H, Williamson DM, Hiyoshi M, Barklis E, Takiguchi M, Suzu S, Gronenborn AM, Smithgall TE, Thomas G.

Mol Biol Cell. 2010 Oct 1;21(19):3279-92. doi: 10.1091/mbc.E10-05-0470. Epub 2010 Aug 11.

3.

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.

Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G.

Mol Biol Cell. 2012 Jun;23(11):2184-97. doi: 10.1091/mbc.E11-11-0928. Epub 2012 Apr 11.

4.

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G.

Cell Host Microbe. 2007 Apr 19;1(2):121-33.

5.

HIV-1 Nef-induced down-regulation of MHC class I requires AP-1 and clathrin but not PACS-1 and is impeded by AP-2.

Lubben NB, Sahlender DA, Motley AM, Lehner PJ, Benaroch P, Robinson MS.

Mol Biol Cell. 2007 Sep;18(9):3351-65. Epub 2007 Jun 20.

6.

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.

Piguet V, Wan L, Borel C, Mangasarian A, Demaurex N, Thomas G, Trono D.

Nat Cell Biol. 2000 Mar;2(3):163-7.

7.

HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.

Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, Hung CH, Thomas G.

Cell. 2002 Dec 13;111(6):853-66.

8.

HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation.

Kumari S, Kumar M, Verma R, Ghosh JK, Tripathi RK.

Life Sci. 2019 Jul 15;229:13-20. doi: 10.1016/j.lfs.2019.04.008. Epub 2019 Apr 3.

PMID:
30953643
9.

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling.

Dirk BS, Pawlak EN, Johnson AL, Van Nynatten LR, Jacob RA, Heit B, Dikeakos JD.

Sci Rep. 2016 Nov 14;6:37021. doi: 10.1038/srep37021.

10.

HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System.

Shi J, Xiong R, Zhou T, Su P, Zhang X, Qiu X, Li H, Li S, Yu C, Wang B, Ding C, Smithgall TE, Zheng YH.

J Virol. 2018 May 14;92(11). pii: e00196-18. doi: 10.1128/JVI.00196-18. Print 2018 Jun 1.

11.
12.

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.

Chase AJ, Wombacher R, Fackler OT.

J Biol Chem. 2018 May 18;293(20):7824-7840. doi: 10.1074/jbc.RA118.002794. Epub 2018 Mar 27.

13.

A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.

Scott GK, Fei H, Thomas L, Medigeshi GR, Thomas G.

EMBO J. 2006 Oct 4;25(19):4423-35. Epub 2006 Sep 14.

14.

The phosphorylation state of an autoregulatory domain controls PACS-1-directed protein traffic.

Scott GK, Gu F, Crump CM, Thomas L, Wan L, Xiang Y, Thomas G.

EMBO J. 2003 Dec 1;22(23):6234-44.

15.

HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.

Yi L, Rosales T, Rose JJ, Chowdhury B, Knutson JR, Venkatesan S.

J Biol Chem. 2010 Oct 1;285(40):30884-905. doi: 10.1074/jbc.M110.135947. Epub 2010 Jul 9. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740. Chaudhury, Bhabhadeb [corrected to Chowdhury, Bhabadeb].

16.

An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex.

Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli JC.

PLoS One. 2009 Dec 18;4(12):e8364. doi: 10.1371/journal.pone.0008364.

17.

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.

Meuwissen PJ, Stolp B, Iannucci V, Vermeire J, Naessens E, Saksela K, Geyer M, Vanham G, Arien KK, Fackler OT, Verhasselt B.

Retrovirology. 2012 Apr 27;9:34. doi: 10.1186/1742-4690-9-34.

19.

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.

Roeth JF, Williams M, Kasper MR, Filzen TM, Collins KL.

J Cell Biol. 2004 Dec 6;167(5):903-13. Epub 2004 Nov 29.

20.

Two sorting motifs, a ubiquitination motif and a tyrosine motif, are involved in HIV-1 and simian immunodeficiency virus Nef-mediated receptor endocytosis.

Cai CY, Zhang X, Sinko PJ, Burakoff SJ, Jin YJ.

J Immunol. 2011 May 15;186(10):5807-14. doi: 10.4049/jimmunol.1003506. Epub 2011 Apr 11.

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