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Items: 1 to 20 of 89

1.

A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin.

Botet J, Rodríguez-Mateos M, Ballesta JP, Revuelta JL, Remacha M.

Antimicrob Agents Chemother. 2008 May;52(5):1623-9. doi: 10.1128/AAC.01603-07. Epub 2008 Feb 19.

2.

Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.

Shastry M, Nielsen J, Ku T, Hsu MJ, Liberator P, Anderson J, Schmatz D, Justice MC.

Microbiology. 2001 Feb;147(Pt 2):383-90.

PMID:
11158355
3.

Structural insights into the mechanism of translational inhibition by the fungicide sordarin.

Chakraborty B, Mukherjee R, Sengupta J.

J Comput Aided Mol Des. 2013 Feb;27(2):173-84. doi: 10.1007/s10822-013-9636-8. Epub 2013 Feb 9.

PMID:
23397219
4.

Mutations in ribosomal protein L10e confer resistance to the fungal-specific eukaryotic elongation factor 2 inhibitor sordarin.

Justice MC, Ku T, Hsu MJ, Carniol K, Schmatz D, Nielsen J.

J Biol Chem. 1999 Feb 19;274(8):4869-75.

5.

Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis.

Justice MC, Hsu MJ, Tse B, Ku T, Balkovec J, Schmatz D, Nielsen J.

J Biol Chem. 1998 Feb 6;273(6):3148-51.

6.

Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid.

Domínguez JM, Gómez-Lorenzo MG, Martín JJ.

J Biol Chem. 1999 Aug 6;274(32):22423-7.

7.

Ribosomal P-protein stalk function is targeted by sordarin antifungals.

Gómez-Lorenzo MG, García-Bustos JF.

J Biol Chem. 1998 Sep 25;273(39):25041-4.

8.

Sordarin derivatives induce a novel conformation of the yeast ribosome translocation factor eEF2.

Søe R, Mosley RT, Justice M, Nielsen-Kahn J, Shastry M, Merrill AR, Andersen GR.

J Biol Chem. 2007 Jan 5;282(1):657-66. Epub 2006 Nov 2.

9.

Ribosomal P0 protein domain involved in selectivity of antifungal sordarin derivatives.

Santos C, Rodríguez-Gabriel MA, Remacha M, Ballesta JP.

Antimicrob Agents Chemother. 2004 Aug;48(8):2930-6.

10.

Hypusine-containing protein eIF5A promotes translation elongation.

Saini P, Eyler DE, Green R, Dever TE.

Nature. 2009 May 7;459(7243):118-21. doi: 10.1038/nature08034.

11.

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.

Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jørgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J.

EMBO J. 2004 Mar 10;23(5):1008-19. Epub 2004 Feb 19.

12.

Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.

Domínguez JM, Kelly VA, Kinsman OS, Marriott MS, Gómez de las Heras F, Martín JJ.

Antimicrob Agents Chemother. 1998 Sep;42(9):2274-8.

13.

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase.

Jørgensen R, Ortiz PA, Carr-Schmid A, Nissen P, Kinzy TG, Andersen GR.

Nat Struct Biol. 2003 May;10(5):379-85. Erratum in: Nat Struct Biol. 2003 Jun;10(7):577.

PMID:
12692531
14.

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.

Bär C, Zabel R, Liu S, Stark MJ, Schaffrath R.

Mol Microbiol. 2008 Sep;69(5):1221-33. doi: 10.1111/j.1365-2958.2008.06350.x. Epub 2008 Jul 4.

15.
16.

A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae.

Arita A, Zhou X, Ellen TP, Liu X, Bai J, Rooney JP, Kurtz A, Klein CB, Dai W, Begley TJ, Costa M.

BMC Genomics. 2009 Nov 15;10:524. doi: 10.1186/1471-2164-10-524.

17.

Chemical-genetic approaches for exploring the mode of action of natural products.

Lopez A, Parsons AB, Nislow C, Giaever G, Boone C.

Prog Drug Res. 2008;66:237, 239-71. Review.

PMID:
18416308
18.

Identification of elongation factor 2 as the essential protein targeted by sordarins in Candida albicans.

Domínguez JM, Martín JJ.

Antimicrob Agents Chemother. 1998 Sep;42(9):2279-83.

19.

Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.

Ortiz PA, Ulloque R, Kihara GK, Zheng H, Kinzy TG.

J Biol Chem. 2006 Oct 27;281(43):32639-48. Epub 2006 Sep 1.

20.

Functional complementation of yeast ribosomal P0 protein with Plasmodium falciparum P0.

Aruna K, Chakraborty T, Rao PN, Santos C, Ballesta JP, Sharma S.

Gene. 2005 Aug 29;357(1):9-17.

PMID:
16099608

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