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Items: 1 to 20 of 176

1.

Parkin mediates the degradation-independent ubiquitination of Hsp70.

Moore DJ, West AB, Dikeman DA, Dawson VL, Dawson TM.

J Neurochem. 2008 Jun;105(5):1806-19. doi: 10.1111/j.1471-4159.2008.05261.x.

2.

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.

Lim KL, Chew KC, Tan JM, Wang C, Chung KK, Zhang Y, Tanaka Y, Smith W, Engelender S, Ross CA, Dawson VL, Dawson TM.

J Neurosci. 2005 Feb 23;25(8):2002-9.

3.

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.

Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O.

Hum Mol Genet. 2006 Jul 1;15(13):2059-75.

4.

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, Xia K, Jiang W, Ronai Z, Zhuang X, Zhang Z.

J Clin Invest. 2009 Mar;119(3):650-60. doi: 10.1172/JCI37617.

5.

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination.

Lim MK, Kawamura T, Ohsawa Y, Ohtsubo M, Asakawa S, Takayanagi A, Shimizu N.

Exp Cell Res. 2007 Aug 1;313(13):2858-74.

PMID:
17512523
6.

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.

Glauser L, Sonnay S, Stafa K, Moore DJ.

J Neurochem. 2011 Aug;118(4):636-45. doi: 10.1111/j.1471-4159.2011.07318.x.

7.

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress.

Moore DJ, Zhang L, Troncoso J, Lee MK, Hattori N, Mizuno Y, Dawson TM, Dawson VL.

Hum Mol Genet. 2005 Jan 1;14(1):71-84.

8.

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.

Science. 2001 Jul 13;293(5528):263-9.

9.

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

Tsai YC, Fishman PS, Thakor NV, Oyler GA.

J Biol Chem. 2003 Jun 13;278(24):22044-55.

10.

Parkin and defective ubiquitination in Parkinson's disease.

Dawson TM.

J Neural Transm Suppl. 2006;(70):209-13. Review.

PMID:
17017531
11.

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease.

Romaní-Aumedes J, Canal M, Martín-Flores N, Sun X, Pérez-Fernández V, Wewering S, Fernández-Santiago R, Ezquerra M, Pont-Sunyer C, Lafuente A, Alberch J, Luebbert H, Tolosa E, Levy OA, Greene LA, Malagelada C.

Cell Death Dis. 2014 Aug 7;5:e1364. doi: 10.1038/cddis.2014.333.

12.

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin.

Ardley HC, Scott GB, Rose SA, Tan NG, Markham AF, Robinson PA.

Mol Biol Cell. 2003 Nov;14(11):4541-56.

13.

Parkin: a multifaceted ubiquitin ligase.

Moore DJ.

Biochem Soc Trans. 2006 Nov;34(Pt 5):749-53.

PMID:
17052189
14.

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1.

Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13354-9.

15.

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

Sriram SR, Li X, Ko HS, Chung KK, Wong E, Lim KL, Dawson VL, Dawson TM.

Hum Mol Genet. 2005 Sep 1;14(17):2571-86.

16.

Parkin ubiquitinates and promotes the degradation of RanBP2.

Um JW, Min DS, Rhim H, Kim J, Paik SR, Chung KC.

J Biol Chem. 2006 Feb 10;281(6):3595-603.

17.

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.

Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM.

Neuron. 2004 Dec 16;44(6):931-45.

18.

Biochemical and Proteomic Analysis of Ubiquitination of Hsc70 and Hsp70 by the E3 Ligase CHIP.

Soss SE, Rose KL, Hill S, Jouan S, Chazin WJ.

PLoS One. 2015 May 26;10(5):e0128240. doi: 10.1371/journal.pone.0128240.

19.
20.

Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.

Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G.

J Biol Chem. 2010 Dec 3;285(49):38214-23. doi: 10.1074/jbc.M110.101469.

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