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Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.

Ranade SS, Yang-Zhou D, Kong SW, McDonald EC, Cook TA, Pignoni F.

Dev Biol. 2008 Mar 15;315(2):521-34. doi: 10.1016/j.ydbio.2007.12.017. Epub 2008 Jan 31.


Evolutionary conservation of otd/Otx2 transcription factor action: a genome-wide microarray analysis in Drosophila.

Montalta-He H, Leemans R, Loop T, Strahm M, Certa U, Primig M, Acampora D, Simeone A, Reichert H.

Genome Biol. 2002;3(4):RESEARCH0015. Epub 2002 Mar 14.


Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse.

Sen S, Reichert H, VijayRaghavan K.

Open Biol. 2013 May 1;3(5):120177. doi: 10.1098/rsob.120177. Review.


OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye.

Terrell D, Xie B, Workman M, Mahato S, Zelhof A, Gebelein B, Cook T.

Dev Dyn. 2012 Jan;241(1):215-28. doi: 10.1002/dvdy.22782. Epub 2011 Nov 23.


Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development.

Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A.

Development. 1998 May;125(9):1691-702.


Otx genes in brain morphogenesis.

Acampora D, Gulisano M, Broccoli V, Simeone A.

Prog Neurobiol. 2001 May;64(1):69-95. Review.


Otx genes in the development and evolution of the vertebrate brain.

Boyl PP, Signore M, Annino A, Barbera JP, Acampora D, Simeone A.

Int J Dev Neurosci. 2001 Jul;19(4):353-63. Review.


Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.

Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring WJ, Finkelstein R, Furukubo-Tokunaga K, Reichert H.

Development. 1998 May;125(9):1703-10.


OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.

Acampora D, Boyl PP, Signore M, Martinez-Barbera JP, Ilengo C, Puelles E, Annino A, Reichert H, Corte G, Simeone A.

Development. 2001 Dec;128(23):4801-13.


Developmental rescue of Drosophila cephalic defects by the human Otx genes.

Nagao T, Leuzinger S, Acampora D, Simeone A, Finkelstein R, Reichert H, Furukubo-Tokunaga K.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3737-42.


Wingless and Hedgehog signaling pathways regulate orthodenticle and eyes absent during ocelli development in Drosophila.

Blanco J, Seimiya M, Pauli T, Reichert H, Gehring WJ.

Dev Biol. 2009 May 1;329(1):104-15. doi: 10.1016/j.ydbio.2009.02.027. Epub 2009 Mar 4.


The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.

Acampora D, Simeone A.

Trends Neurosci. 1999 Mar;22(3):116-22.


Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx.

Satterlee JS, Sasakura H, Kuhara A, Berkeley M, Mori I, Sengupta P.

Neuron. 2001 Sep 27;31(6):943-56.


Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events.

McDonald EC, Xie B, Workman M, Charlton-Perkins M, Terrell DA, Reischl J, Wimmer EA, Gebelein BA, Cook TA.

Dev Biol. 2010 Nov 1;347(1):122-32. doi: 10.1016/j.ydbio.2010.08.016. Epub 2010 Aug 21.


Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?

Acampora D, Boyl PP, Martinez-Barbera JP, Annino A, Signore M, Simeone A.

J Anat. 2001 Jul-Aug;199(Pt 1-2):53-62. Review.


Genetic and molecular roles of Otx homeodomain proteins in head development.

Acampora D, Gulisano M, Simeone A.

Gene. 2000 Apr 4;246(1-2):23-35. Review.


An urbilaterian origin of the tripartite brain: developmental genetic insights from Drosophila.

Hirth F, Kammermeier L, Frei E, Walldorf U, Noll M, Reichert H.

Development. 2003 Jun;130(11):2365-73.


Cross-phylum regulatory potential of the ascidian Otx gene in brain development in Drosophila melanogaster.

Adachi Y, Nagao T, Saiga H, Furukubo-Tokunaga K.

Dev Genes Evol. 2001 Jun;211(6):269-80.


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