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Items: 1 to 20 of 106

1.

Nervous system KV7 disorders: breakdown of a subthreshold brake.

Maljevic S, Wuttke TV, Lerche H.

J Physiol. 2008 Apr 1;586(7):1791-801. doi: 10.1113/jphysiol.2008.150656. Epub 2008 Jan 31. Review.

2.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M.

J Neurosci. 2005 May 18;25(20):5051-60.

3.

Potent KCNQ2/3-specific channel activator suppresses in vivo epileptic activity and prevents the development of tinnitus.

Kalappa BI, Soh H, Duignan KM, Furuya T, Edwards S, Tzingounis AV, Tzounopoulos T.

J Neurosci. 2015 Jun 10;35(23):8829-42. doi: 10.1523/JNEUROSCI.5176-14.2015.

4.

The therapeutic potential of neuronal KCNQ channel modulators.

Gribkoff VK.

Expert Opin Ther Targets. 2003 Dec;7(6):737-48. Review.

PMID:
14640909
5.

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy.

Gunthorpe MJ, Large CH, Sankar R.

Epilepsia. 2012 Mar;53(3):412-24. doi: 10.1111/j.1528-1167.2011.03365.x. Epub 2012 Jan 5. Review.

6.

Potassium channel genes and benign familial neonatal epilepsy.

Maljevic S, Lerche H.

Prog Brain Res. 2014;213:17-53. doi: 10.1016/B978-0-444-63326-2.00002-8. Review.

PMID:
25194482
7.

Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs.

Miceli F, Soldovieri MV, Martire M, Taglialatela M.

Curr Opin Pharmacol. 2008 Feb;8(1):65-74. Epub 2007 Dec 3. Review.

PMID:
18061539
8.

Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations.

Wuttke TV, Jurkat-Rott K, Paulus W, Garncarek M, Lehmann-Horn F, Lerche H.

Neurology. 2007 Nov 27;69(22):2045-53. Epub 2007 Sep 13.

PMID:
17872363
10.

Retigabine: chemical synthesis to clinical application.

Blackburn-Munro G, Dalby-Brown W, Mirza NR, Mikkelsen JD, Blackburn-Munro RE.

CNS Drug Rev. 2005 Spring;11(1):1-20. Review.

11.

KV7 channelopathies.

Maljevic S, Wuttke TV, Seebohm G, Lerche H.

Pflugers Arch. 2010 Jul;460(2):277-88. doi: 10.1007/s00424-010-0831-3. Epub 2010 Apr 18. Review.

PMID:
20401729
12.

Dominant-negative effects of KCNQ2 mutations are associated with epileptic encephalopathy.

Orhan G, Bock M, Schepers D, Ilina EI, Reichel SN, Löffler H, Jezutkovic N, Weckhuysen S, Mandelstam S, Suls A, Danker T, Guenther E, Scheffer IE, De Jonghe P, Lerche H, Maljevic S.

Ann Neurol. 2014 Mar;75(3):382-94. doi: 10.1002/ana.24080. Epub 2014 Mar 18.

PMID:
24318194
13.

Genetic testing in benign familial epilepsies of the first year of life: clinical and diagnostic significance.

Zara F, Specchio N, Striano P, Robbiano A, Gennaro E, Paravidino R, Vanni N, Beccaria F, Capovilla G, Bianchi A, Caffi L, Cardilli V, Darra F, Bernardina BD, Fusco L, Gaggero R, Giordano L, Guerrini R, Incorpora G, Mastrangelo M, Spaccini L, Laverda AM, Vecchi M, Vanadia F, Veggiotti P, Viri M, Occhi G, Budetta M, Taglialatela M, Coviello DA, Vigevano F, Minetti C.

Epilepsia. 2013 Mar;54(3):425-36. doi: 10.1111/epi.12089. Epub 2013 Jan 29.

14.

Genotype-phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of K(v)7.2 potassium channel subunits.

Miceli F, Soldovieri MV, Ambrosino P, Barrese V, Migliore M, Cilio MR, Taglialatela M.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4386-91. doi: 10.1073/pnas.1216867110. Epub 2013 Feb 25.

15.
16.

Neutralization of a negative charge in the S1-S2 region of the KV7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy.

Wuttke TV, Penzien J, Fauler M, Seebohm G, Lehmann-Horn F, Lerche H, Jurkat-Rott K.

J Physiol. 2008 Jan 15;586(2):545-55. Epub 2007 Nov 15.

17.

A novel mutation in KCNQ2 associated with BFNC, drug resistant epilepsy, and mental retardation.

Borgatti R, Zucca C, Cavallini A, Ferrario M, Panzeri C, Castaldo P, Soldovieri MV, Baschirotto C, Bresolin N, Dalla Bernardina B, Taglialatela M, Bassi MT.

Neurology. 2004 Jul 13;63(1):57-65.

PMID:
15249611
18.

Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K+ channel.

Dedek K, Kunath B, Kananura C, Reuner U, Jentsch TJ, Steinlein OK.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12272-7. Epub 2001 Sep 25.

19.

Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.

Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M.

J Neurosci. 2015 Mar 4;35(9):3782-93. doi: 10.1523/JNEUROSCI.4423-14.2015.

20.

M-channels: neurological diseases, neuromodulation, and drug development.

Cooper EC, Jan LY.

Arch Neurol. 2003 Apr;60(4):496-500. Review.

PMID:
12707061

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