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Items: 1 to 20 of 316

1.

Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways.

Dogusan Z, García M, Flamez D, Alexopoulou L, Goldman M, Gysemans C, Mathieu C, Libert C, Eizirik DL, Rasschaert J.

Diabetes. 2008 May;57(5):1236-45. doi: 10.2337/db07-0844. Epub 2008 Jan 25.

2.

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells.

Rasschaert J, Ladrière L, Urbain M, Dogusan Z, Katabua B, Sato S, Akira S, Gysemans C, Mathieu C, Eizirik DL.

J Biol Chem. 2005 Oct 7;280(40):33984-91. Epub 2005 Jul 15.

3.

Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.

Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E.

J Biol Chem. 2007 May 18;282(20):15022-32. Epub 2007 Feb 12.

4.

Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.

García M, Dogusan Z, Moore F, Sato S, Hartmann G, Eizirik DL, Rasschaert J.

Biochim Biophys Acta. 2009 Nov;1793(11):1768-75. doi: 10.1016/j.bbamcr.2009.09.005. Epub 2009 Sep 10.

5.

Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.

Dong LW, Kong XN, Yan HX, Yu LX, Chen L, Yang W, Liu Q, Huang DD, Wu MC, Wang HY.

Mol Immunol. 2008 Jun;45(11):3025-35. doi: 10.1016/j.molimm.2008.03.012. Epub 2008 May 8.

PMID:
18471880
6.

Microglia recognize double-stranded RNA via TLR3.

Town T, Jeng D, Alexopoulou L, Tan J, Flavell RA.

J Immunol. 2006 Mar 15;176(6):3804-12.

7.

Double-stranded RNA induces iNOS gene expression in Schwann cells, sensory neuronal death, and peripheral nerve demyelination.

Lee H, Park C, Cho IH, Kim HY, Jo EK, Lee S, Kho HS, Choi SY, Oh SB, Park K, Kim JS, Lee SJ.

Glia. 2007 May;55(7):712-22.

PMID:
17348024
8.

NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.

Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T.

J Immunol. 2006 Dec 15;177(12):8676-83.

9.

Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappaB and/or IRF-3 in airway epithelial cells.

Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, Adachi M.

Clin Exp Allergy. 2006 Aug;36(8):1049-62.

PMID:
16911361
10.

Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.

Kulka M, Alexopoulou L, Flavell RA, Metcalfe DD.

J Allergy Clin Immunol. 2004 Jul;114(1):174-82.

PMID:
15241362
11.

Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis.

Yoneda K, Sugimoto K, Shiraki K, Tanaka J, Beppu T, Fuke H, Yamamoto N, Masuya M, Horie R, Uchida K, Takei Y.

Int J Oncol. 2008 Nov;33(5):929-36.

PMID:
18949355
12.

Double-stranded RNA induces melanocyte death via activation of Toll-like receptor 3.

Yu N, Zhang S, Sun T, Kang K, Guan M, Xiang L.

Exp Dermatol. 2011 Feb;20(2):134-9. doi: 10.1111/j.1600-0625.2010.01208.x.

PMID:
21255093
13.

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.

Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T.

Biochem Biophys Res Commun. 2002 May 24;293(5):1364-9.

PMID:
12054664
14.

p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.

Pisegna S, Pirozzi G, Piccoli M, Frati L, Santoni A, Palmieri G.

Blood. 2004 Dec 15;104(13):4157-64. Epub 2004 Aug 17.

15.

The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.

Itoh K, Watanabe A, Funami K, Seya T, Matsumoto M.

J Immunol. 2008 Oct 15;181(8):5522-9.

16.
17.

TLR3 signaling in a hepatoma cell line is skewed towards apoptosis.

Khvalevsky E, Rivkin L, Rachmilewitz J, Galun E, Giladi H.

J Cell Biochem. 2007 Apr 1;100(5):1301-12.

PMID:
17243100
18.

Poly I:C enhances cycloheximide-induced apoptosis of tumor cells through TLR3 pathway.

Jiang Q, Wei H, Tian Z.

BMC Cancer. 2008 Jan 17;8:12. doi: 10.1186/1471-2407-8-12.

20.

Toll-like receptor 3 ligand-induced antiviral response in mouse osteoblastic cells.

Nakamura K, Deyama Y, Yoshimura Y, Suzuki K, Morita M.

Int J Mol Med. 2007 May;19(5):771-5.

PMID:
17390082

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