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Items: 1 to 20 of 76

1.

Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.

Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG.

Cancer Res. 2008 Jan 15;68(2):605-14. doi: 10.1158/0008-5472.CAN-07-5472.

2.

Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells.

Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, Bristow RG.

Radiother Oncol. 2005 Aug;76(2):168-76.

PMID:
16026872
3.

Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity.

Choudhury A, Zhao H, Jalali F, Al Rashid S, Ran J, Supiot S, Kiltie AE, Bristow RG.

Mol Cancer Ther. 2009 Jan;8(1):203-13. doi: 10.1158/1535-7163.MCT-08-0959.

4.

Increased radiosensitivity with chronic hypoxia in four human tumor cell lines.

Zölzer F, Streffer C.

Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):910-20.

PMID:
12377345
5.

Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status.

Sprong D, Janssen HL, Vens C, Begg AC.

Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):562-72. Epub 2005 Dec 15.

PMID:
16343804
6.

Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.

Yu D, Sekine E, Fujimori A, Ochiya T, Okayasu R.

Cancer Sci. 2008 Apr;99(4):810-5. doi: 10.1111/j.1349-7006.2008.00741.x.

7.

Tumor hypoxia as a modifier of DNA strand break and cross-link repair.

Chan N, Koch CJ, Bristow RG.

Curr Mol Med. 2009 May;9(4):401-10. Review.

PMID:
19519397
8.

Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance.

Henning W, Stürzbecher HW.

Toxicology. 2003 Nov 15;193(1-2):91-109. Review.

PMID:
14599770
9.

WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells.

Cuddihy AR, Jalali F, Coackley C, Bristow RG.

Mol Cancer Ther. 2008 Apr;7(4):980-92. doi: 10.1158/1535-7163.MCT-07-0471.

10.

Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A.

Gu Y, Patterson AV, Atwell GJ, Chernikova SB, Brown JM, Thompson LH, Wilson WR.

Mol Cancer Ther. 2009 Jun;8(6):1714-23. doi: 10.1158/1535-7163.MCT-08-1209. Epub 2009 Jun 9.

11.

Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells.

Vernole P, Muzi A, Volpi A, Dorio AS, Terrinoni A, Shah GM, Graziani G.

Mutat Res. 2009 May 12;664(1-2):39-47. doi: 10.1016/j.mrfmmm.2009.02.005. Epub 2009 Feb 21.

PMID:
19428379
12.

Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell SN, Kachnic LA.

Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.

PMID:
18473729
13.

Regulation of DNA repair in hypoxic cancer cells.

Bindra RS, Crosby ME, Glazer PM.

Cancer Metastasis Rev. 2007 Jun;26(2):249-60. Review.

PMID:
17415527
14.

Altered DNA repair and recombination responses in mouse cells expressing wildtype or mutant forms of RAD51.

Rukść A, Birmingham EC, Baker MD.

DNA Repair (Amst). 2007 Dec 1;6(12):1876-89. Epub 2007 Aug 24.

PMID:
17719855
15.
16.

ERCC1/ERCC4 5'-endonuclease activity as a determinant of hypoxic cell radiosensitivity.

Murray D, Macann A, Hanson J, Rosenberg E.

Int J Radiat Biol. 1996 Mar;69(3):319-27.

PMID:
8613681
17.

The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination.

Zhao H, Luoto KR, Meng AX, Bristow RG.

Radiother Oncol. 2011 Oct;101(1):59-65. doi: 10.1016/j.radonc.2011.08.013. Epub 2011 Sep 6.

PMID:
21903282
18.

Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.

Koehn H, Magan N, Isaacs RJ, Stowell KM.

Anticancer Drugs. 2007 Apr;18(4):419-25.

PMID:
17351394
19.

Impact of homologous recombination on individual cellular radiosensitivity.

Koch K, Wrona A, Dikomey E, Borgmann K.

Radiother Oncol. 2009 Feb;90(2):265-72. doi: 10.1016/j.radonc.2008.07.028. Epub 2008 Sep 17.

PMID:
18804300
20.

Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions.

Isohashi F, Endo H, Mukai M, Inoue T, Inoue M.

Cancer Sci. 2008 Dec;99(12):2395-401. doi: 10.1111/j.1349-7006.2008.00970.x. Epub 2008 Nov 17.

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