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Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.

Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E540-50. doi: 10.1152/ajpendo.00478.2007. Epub 2008 Jan 15.


Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.

Green CD, Olson LK.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E640-9. doi: 10.1152/ajpendo.00544.2010. Epub 2011 Jan 25.


Thapsigargin down-regulates protein levels of GRP78/BiP in INS-1E cells.

Rosengren V, Johansson H, Lehtiö J, Fransson L, Sjöholm A, Ortsäter H.

J Cell Biochem. 2012 May;113(5):1635-44. doi: 10.1002/jcb.24032.


A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose-stimulated insulin secretion (GSIS).

Choi SE, Lee YJ, Jang HJ, Lee KW, Kim YS, Jun HS, Kang SS, Chun J, Kang Y.

Arch Biochem Biophys. 2008 Jul 15;475(2):109-14. doi: 10.1016/ Epub 2008 Apr 18.


Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells.

Gwiazda KS, Yang TL, Lin Y, Johnson JD.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E690-701. doi: 10.1152/ajpendo.90525.2008. Epub 2009 Jan 13.


Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.

Thörn K, Hovsepyan M, Bergsten P.

Lipids Health Dis. 2010 Sep 29;9:108. doi: 10.1186/1476-511X-9-108.


Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.

Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):770-6. doi: 10.1016/j.bbrc.2013.10.130. Epub 2013 Nov 1.


A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, Fuller M, Laybutt DR, Meikle PJ, Biden TJ.

Biochem J. 2011 Apr 1;435(1):267-76. doi: 10.1042/BJ20101867. Erratum in: Biochem J. 2011 Nov 1;439(3):517-8.


WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.

Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, Aburatani H, Miyazaki J, Oka Y.

Hum Mol Genet. 2006 May 15;15(10):1600-9. Epub 2006 Mar 28.


Tauroursodeoxycholate, a chemical chaperone, prevents palmitate-induced apoptosis in pancreatic β-cells by reducing ER stress.

Zhu Q, Zhong JJ, Jin JF, Yin XM, Miao H.

Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):43-7. doi: 10.1055/s-0032-1321787. Epub 2012 Sep 12.


Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.

Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E.

Diabetes. 2009 Aug;58(8):1757-65. doi: 10.2337/db09-0188. Epub 2009 May 28.


H2S, endoplasmic reticulum stress, and apoptosis of insulin-secreting beta cells.

Yang G, Yang W, Wu L, Wang R.

J Biol Chem. 2007 Jun 1;282(22):16567-76. Epub 2007 Apr 12.


Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A.

Endocrinology. 2006 Jul;147(7):3398-407. Epub 2006 Apr 6.


Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.

Wei Y, Wang D, Topczewski F, Pagliassotti MJ.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E275-81. Epub 2006 Feb 21.


Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ.

Diabetes. 2005 Oct;54(10):2917-24.


Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate.

Thörn K, Bergsten P.

J Cell Biochem. 2010 Oct 1;111(2):497-507. doi: 10.1002/jcb.22734.


Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes.

Guo W, Wong S, Xie W, Lei T, Luo Z.

Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E576-86. Epub 2007 May 22.


Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis.

Wu J, Sun P, Zhang X, Liu H, Jiang H, Zhu W, Wang H.

J Cell Biochem. 2012 Apr;113(4):1152-8. doi: 10.1002/jcb.23450. Erratum in: J Cell Biochem. 2013 May;114(5):1216.


Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.


Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis.

Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD, Hersey P.

Cancer Res. 2007 Oct 15;67(20):9750-61.

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