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Items: 1 to 20 of 246

1.

COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity.

Fenalti G, Hampe CS, Arafat Y, Law RH, Banga JP, Mackay IR, Whisstock JC, Buckle AM, Rowley MJ.

Diabetes. 2008 May;57(5):1293-301. doi: 10.2337/db07-1461. Epub 2008 Jan 9.

2.

The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera.

Tong JC, Myers MA, Mackay IR, Zimmet PZ, Rowley MJ.

Ann N Y Acad Sci. 2002 Apr;958:182-9.

PMID:
12021103
3.

Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling.

Myers MA, Davies JM, Tong JC, Whisstock J, Scealy M, Mackay IR, Rowley MJ.

J Immunol. 2000 Oct 1;165(7):3830-8.

4.

Structural determinants of GAD antigenicity.

Arafat Y, Fenalti G, Whisstock JC, Mackay IR, Garcia de la Banda M, Rowley MJ, Buckle AM.

Mol Immunol. 2009 Dec;47(2-3):493-505. doi: 10.1016/j.molimm.2009.08.022. Epub 2009 Sep 23.

PMID:
19783309
5.

GAD65 as a prototypic autoantigen.

Fenalti G, Rowley MJ.

J Autoimmun. 2008 Nov;31(3):228-32. doi: 10.1016/j.jaut.2008.04.013. Epub 2008 Jun 2.

PMID:
18514483
6.

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11.

Fenalti G, Hampe CS, O'connor K, Banga JP, Mackay IR, Rowley MJ, El-Kabbani O.

Mol Immunol. 2007 Feb;44(6):1178-89. Epub 2006 Aug 22.

PMID:
16930708
7.

High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.

Schwartz HL, Chandonia JM, Kash SF, Kanaani J, Tunnell E, Domingo A, Cohen FE, Banga JP, Madec AM, Richter W, Baekkeskov S.

J Mol Biol. 1999 Apr 16;287(5):983-99.

PMID:
10222205
8.

Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase.

Syren K, Lindsay L, Stoehrer B, Jury K, Lühder F, Baekkeskov S, Richter W.

J Immunol. 1996 Dec 1;157(11):5208-14.

PMID:
8943434
9.

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401.

Wicker LS, Chen SL, Nepom GT, Elliott JF, Freed DC, Bansal A, Zheng S, Herman A, Lernmark A, Zaller DM, Peterson LB, Rothbard JB, Cummings R, Whiteley PJ.

J Clin Invest. 1996 Dec 1;98(11):2597-603.

10.

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients.

Endl J, Otto H, Jung G, Dreisbusch B, Donie F, Stahl P, Elbracht R, Schmitz G, Meinl E, Hummel M, Ziegler AG, Wank R, Schendel DJ.

J Clin Invest. 1997 May 15;99(10):2405-15.

11.

Murine monoclonal glutamic acid decarboxylase (GAD)65 antibodies recognize autoimmune-associated GAD epitope regions targeted in patients with type 1 diabetes mellitus and stiff-man syndrome.

Ziegler B, Schlosser M, Lühder F, Strebelow M, Augstein P, Northemann W, Powers AC, Ziegler M.

Acta Diabetol. 1996 Sep;33(3):225-31.

PMID:
8904930
12.

Identification of glutamic acid decarboxylase autoantibody heterogeneity and epitope regions in type I diabetes.

Ujihara N, Daw K, Gianani R, Boel E, Yu L, Powers AC.

Diabetes. 1994 Aug;43(8):968-75.

PMID:
8039604
13.
14.

HLA-DR binding analysis of peptides from islet antigens in IDDM.

Geluk A, van Meijgaarden KE, Schloot NC, Drijfhout JW, Ottenhoff TH, Roep BO.

Diabetes. 1998 Oct;47(10):1594-601.

PMID:
9753297
16.
17.

Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition.

Primo ME, Anton EA, Villanueva AL, Poskus E, Ermácora MR.

Clin Immunol. 2003 Jul;108(1):38-45.

PMID:
12865069
18.

Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group.

Söhnlein P, Müller M, Syren K, Hartmann U, Böhm BO, Meinck HM, Knip M, Akerblom HK, Richter W.

Diabetologia. 2000 Feb;43(2):210-7.

PMID:
10753043
19.
20.

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