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Items: 1 to 20 of 116

1.

Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood.

Miao XS, Song P, Savage RE, Zhong C, Yang RY, Kizer D, Wu H, Volckova E, Ashwell MA, Supko JG, He X, Chan TC.

Drug Metab Dispos. 2008 Apr;36(4):641-8. doi: 10.1124/dmd.107.018572. Epub 2008 Jan 7.

2.

In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells.

Miao XS, Zhong C, Wang Y, Savage RE, Yang RY, Kizer D, Volckova E, Ashwell MA, Chan TC.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):12-22. doi: 10.1002/rcm.3835.

PMID:
19051226
3.

Synthetic methods for the preparation of ARQ 501 (beta-Lapachone) human blood metabolites.

Yang RY, Kizer D, Wu H, Volckova E, Miao XS, Ali SM, Tandon M, Savage RE, Chan TC, Ashwell MA.

Bioorg Med Chem. 2008 May 15;16(10):5635-43. doi: 10.1016/j.bmc.2008.03.073. Epub 2008 Apr 1.

PMID:
18424157
4.

Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.

Savage RE, Tyler AN, Miao XS, Chan TC.

Drug Metab Dispos. 2008 Apr;36(4):753-8. doi: 10.1124/dmd.107.018655. Epub 2008 Jan 28.

5.

Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry.

Lee S, Kim IS, Kwak TH, Yoo HH.

J Pharm Biomed Anal. 2013 Sep;83:286-92. doi: 10.1016/j.jpba.2013.05.028. Epub 2013 May 28.

PMID:
23777616
6.

Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts.

Savage RE, Hall T, Bresciano K, Bailey J, Starace M, Chan TC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):148-53. doi: 10.1016/j.jchromb.2008.07.031. Epub 2008 Jul 31.

PMID:
18706870
7.

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG.

Drug Metab Dispos. 2007 Jan;35(1):150-67. Epub 2006 Oct 24.

8.

In vivo metabolism of [14C]ruboxistaurin in dogs, mice, and rats following oral administration and the structure determination of its metabolites by liquid chromatography/mass spectrometry and NMR spectroscopy.

Barbuch RJ, Campanale K, Hadden CE, Zmijewski M, Yi P, O'Bannon DD, Burkey JL, Kulanthaivel P.

Drug Metab Dispos. 2006 Feb;34(2):213-24. Epub 2005 Oct 28.

9.

Metabolism and excretion of loratadine in male and female mice, rats and monkeys.

Ramanathan R, Alvarez N, Su AD, Chowdhury S, Alton K, Stauber K, Patrick J.

Xenobiotica. 2005 Feb;35(2):155-89.

PMID:
16019945
10.

Metabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin) in animals and humans.

Wu WN, McKown LA, Moyer MD, Cheung W.

Xenobiotica. 2004 Jun;34(6):591-606.

PMID:
15277018
11.

Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs.

Zhang D, Raghavan N, Chen SY, Zhang H, Quan M, Lecureux L, Patrone LM, Lam PY, Bonacorsi SJ, Knabb RM, Skiles GL, He K.

Drug Metab Dispos. 2008 Feb;36(2):303-15. Epub 2007 Nov 5.

12.

Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human.

Carmo H, Hengstler JG, de Boer D, Ringel M, Remião F, Carvalho F, Fernandes E, dos Reys LA, Oesch F, de Lourdes Bastos M.

Toxicology. 2005 Jan 5;206(1):75-89.

PMID:
15590110
13.

Evaluation of the metabolism of propranolol by linear ion trap technology in mouse, rat, dog, monkey, and human cryopreserved hepatocytes.

Baughman TM, Talarico CL, Soglia JR.

Rapid Commun Mass Spectrom. 2009 Jul;23(14):2146-50. doi: 10.1002/rcm.4130.

PMID:
19517456
14.

Rapid biotransformation of satraplatin by human red blood cells in vitro.

Carr JL, Tingle MD, McKeage MJ.

Cancer Chemother Pharmacol. 2002 Jul;50(1):9-15. Epub 2002 May 22.

PMID:
12111106
15.

The metabolism of piperidine-type phenothiazine antipsychotic agents. II. Sulforidazine in dog and human.

Lin G, Hawes EM, McKay G, Cooper SF, Korchinski ED, Midha KK.

Xenobiotica. 1993 Jan;23(1):27-36.

PMID:
8097899
16.

Metabolism of prazosin in rat and characterization of metabolites in plasma, urine, faeces, brain and bile using liquid chromatography/mass spectrometry (LC/MS).

Erve JC, Vashishtha SC, Ojewoye O, Adedoyin A, Espina R, Demaio W, Talaat RE.

Xenobiotica. 2008 May;38(5):540-58. doi: 10.1080/00498250802001826 .

PMID:
18421626
18.

Identification of metabolites of meisoindigo in rat, pig and human liver microsomes by UFLC-MS/MS.

Huang M, Ho PC.

Biochem Pharmacol. 2009 Apr 15;77(8):1418-28. doi: 10.1016/j.bcp.2009.01.012. Epub 2009 Jan 29.

PMID:
19426681
19.

New metabolic pathways of alpha-lipoic acid.

Schupke H, Hempel R, Peter G, Hermann R, Wessel K, Engel J, Kronbach T.

Drug Metab Dispos. 2001 Jun;29(6):855-62.

20.

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