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The scoop on the fly brain: glial engulfment functions in Drosophila.

Logan MA, Freeman MR.

Neuron Glia Biol. 2007 Feb;3(1):63-74. doi: 10.1017/S1740925X07000646.


Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons.

Tasdemir-Yilmaz OE, Freeman MR.

Genes Dev. 2014 Jan 1;28(1):20-33. doi: 10.1101/gad.229518.113. Epub 2013 Dec 20.


Keeping the CNS clear: glial phagocytic functions in Drosophila.

Kurant E.

Glia. 2011 Sep;59(9):1304-11. doi: 10.1002/glia.21098. Epub 2010 Dec 6. Review.


Protein phosphatase 4 coordinates glial membrane recruitment and phagocytic clearance of degenerating axons in Drosophila.

Winfree LM, Speese SD, Logan MA.

Cell Death Dis. 2017 Feb 23;8(2):e2623. doi: 10.1038/cddis.2017.40.


Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis.

Awasaki T, Tatsumi R, Takahashi K, Arai K, Nakanishi Y, Ueda R, Ito K.

Neuron. 2006 Jun 15;50(6):855-67.


The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function.

Macdonald JM, Doherty J, Hackett R, Freeman MR.

Cell Death Differ. 2013 Sep;20(9):1140-8. doi: 10.1038/cdd.2013.30. Epub 2013 Apr 26.


Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury.

Logan MA, Hackett R, Doherty J, Sheehan A, Speese SD, Freeman MR.

Nat Neurosci. 2012 Mar 18;15(5):722-30. doi: 10.1038/nn.3066.


Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy.

Ziegenfuss JS, Doherty J, Freeman MR.

Nat Neurosci. 2012 Jun 17;15(7):979-87. doi: 10.1038/nn.3135.


Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity.

Purice MD, Speese SD, Logan MA.

Nat Commun. 2016 Sep 20;7:12871. doi: 10.1038/ncomms12871.


Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.

Ziegenfuss JS, Biswas R, Avery MA, Hong K, Sheehan AE, Yeung YG, Stanley ER, Freeman MR.

Nature. 2008 Jun 12;453(7197):935-9. doi: 10.1038/nature06901. Epub 2008 Apr 23.


A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade.

Purice MD, Ray A, Münzel EJ, Pope BJ, Park DJ, Speese SD, Logan MA.

Elife. 2017 Aug 21;6. pii: e23611. doi: 10.7554/eLife.23611.


Glial cells phagocytose neuronal debris during the metamorphosis of the central nervous system in Drosophila melanogaster.

Cantera R, Technau GM.

Dev Genes Evol. 1996 Nov;206(4):277-80. doi: 10.1007/s004270050052.


Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.

Pearce MM, Spartz EJ, Hong W, Luo L, Kopito RR.

Nat Commun. 2015 Apr 13;6:6768. doi: 10.1038/ncomms7768.


DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.

Lu TY, Doherty J, Freeman MR.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12544-9. doi: 10.1073/pnas.1403450111. Epub 2014 Aug 6.


JNK pathway activation is able to synchronize neuronal death and glial phagocytosis in Drosophila.

Shklover J, Mishnaevski K, Levy-Adam F, Kurant E.

Cell Death Dis. 2015 Feb 19;6:e1649. doi: 10.1038/cddis.2015.27.


Organization and postembryonic development of glial cells in the adult central brain of Drosophila.

Awasaki T, Lai SL, Ito K, Lee T.

J Neurosci. 2008 Dec 17;28(51):13742-53. doi: 10.1523/JNEUROSCI.4844-08.2008.


Ensheathing glia function as phagocytes in the adult Drosophila brain.

Doherty J, Logan MA, Taşdemir OE, Freeman MR.

J Neurosci. 2009 Apr 15;29(15):4768-81. doi: 10.1523/JNEUROSCI.5951-08.2009.


The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons.

MacDonald JM, Beach MG, Porpiglia E, Sheehan AE, Watts RJ, Freeman MR.

Neuron. 2006 Jun 15;50(6):869-81.


Phagocytosis Assay for Apoptotic Cells in Drosophila Embryos.

Nonaka S, Hori A, Nakanishi Y, Kuraishi T.

J Vis Exp. 2017 Aug 3;(126). doi: 10.3791/56352.


Glial contributions to neuronal health and disease: new insights from Drosophila.

Logan MA.

Curr Opin Neurobiol. 2017 Oct 30;47:162-167. doi: 10.1016/j.conb.2017.10.008. [Epub ahead of print] Review.


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