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Items: 1 to 20 of 129


Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.

Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A.

Diabetes. 2008 Apr;57(4):938-44. doi: 10.2337/db07-0715. Epub 2008 Jan 2.


Lack of TXNIP protects beta-cells against glucotoxicity.

Shalev A.

Biochem Soc Trans. 2008 Oct;36(Pt 5):963-5. doi: 10.1042/BST0360963.


Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death.

Chen J, Fontes G, Saxena G, Poitout V, Shalev A.

Diabetes. 2010 Feb;59(2):440-7. doi: 10.2337/db09-0949. Epub 2009 Oct 29.


Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

Shaked M, Ketzinel-Gilad M, Ariav Y, Cerasi E, Kaiser N, Leibowitz G.

Diabetologia. 2009 Apr;52(4):636-44. doi: 10.1007/s00125-009-1274-2. Epub 2009 Feb 13.


High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

Masson E, Koren S, Razik F, Goldberg H, Kwan EP, Sheu L, Gaisano HY, Fantus IG.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1251-61. doi: 10.1152/ajpendo.90619.2008. Epub 2009 Feb 17.


Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis.

Minn AH, Hafele C, Shalev A.

Endocrinology. 2005 May;146(5):2397-405. Epub 2005 Feb 10.


Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A.

FASEB J. 2008 Oct;22(10):3581-94. doi: 10.1096/fj.08-111690. Epub 2008 Jun 13.


Diabetes induces and calcium channel blockers prevent cardiac expression of proapoptotic thioredoxin-interacting protein.

Chen J, Cha-Molstad H, Szabo A, Shalev A.

Am J Physiol Endocrinol Metab. 2009 May;296(5):E1133-9. doi: 10.1152/ajpendo.90944.2008. Epub 2009 Mar 3.


Preventing β-cell loss and diabetes with calcium channel blockers.

Xu G, Chen J, Jing G, Shalev A.

Diabetes. 2012 Apr;61(4):848-56. doi: 10.2337/db11-0955.


Involvement of thioredoxin-interacting protein (TXNIP) in glucocorticoid-mediated beta cell death.

Reich E, Tamary A, Sionov RV, Melloul D.

Diabetologia. 2012 Apr;55(4):1048-57. doi: 10.1007/s00125-011-2422-z. Epub 2012 Jan 14.


MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis.

Filios SR, Xu G, Chen J, Hong K, Jing G, Shalev A.

J Biol Chem. 2014 Dec 26;289(52):36275-83. doi: 10.1074/jbc.M114.592360. Epub 2014 Nov 12.


Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2.

Jing G, Westwell-Roper C, Chen J, Xu G, Verchere CB, Shalev A.

J Biol Chem. 2014 Apr 25;289(17):11807-15. doi: 10.1074/jbc.M113.525022. Epub 2014 Mar 13.


Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells.

Cha-Molstad H, Saxena G, Chen J, Shalev A.

J Biol Chem. 2009 Jun 19;284(25):16898-905. doi: 10.1074/jbc.M109.010504. Epub 2009 May 1.


Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein.

Saxena G, Chen J, Shalev A.

J Biol Chem. 2010 Feb 5;285(6):3997-4005. doi: 10.1074/jbc.M109.034421. Epub 2009 Dec 3.


Transcription factor Ets1 regulates expression of thioredoxin-interacting protein and inhibits insulin secretion in pancreatic β-cells.

Luo Y, He F, Hu L, Hai L, Huang M, Xu Z, Zhang J, Zhou Z, Liu F, Dai YS.

PLoS One. 2014 Jun 4;9(6):e99049. doi: 10.1371/journal.pone.0099049. eCollection 2014.


Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein.

Chen J, Couto FM, Minn AH, Shalev A.

Biochem Biophys Res Commun. 2006 Aug 4;346(3):1067-74. Epub 2006 Jun 13.


Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.

Xu G, Chen J, Jing G, Shalev A.

Nat Med. 2013 Sep;19(9):1141-6. doi: 10.1038/nm.3287. Epub 2013 Aug 25.


AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells.

Shaked M, Ketzinel-Gilad M, Cerasi E, Kaiser N, Leibowitz G.

PLoS One. 2011;6(12):e28804. doi: 10.1371/journal.pone.0028804. Epub 2011 Dec 14. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/23f84cc3-627d-4012-ae6f-f3291b2567d0.


Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.

Hong K, Xu G, Grayson TB, Shalev A.

J Biol Chem. 2016 Apr 15;291(16):8428-39. doi: 10.1074/jbc.M115.698365. Epub 2016 Feb 8.


Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets.

Costes S, Vandewalle B, Tourrel-Cuzin C, Broca C, Linck N, Bertrand G, Kerr-Conte J, Portha B, Pattou F, Bockaert J, Dalle S.

Diabetes. 2009 May;58(5):1105-15. doi: 10.2337/db08-0926. Epub 2009 Feb 17.

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