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Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation.

Chen Z, Laurence A, O'Shea JJ.

Semin Immunol. 2007 Dec;19(6):400-8. doi: 10.1016/j.smim.2007.10.015. Epub 2007 Dec 31. Review.


Transcriptional regulation of Th17 cell differentiation.

Ivanov II, Zhou L, Littman DR.

Semin Immunol. 2007 Dec;19(6):409-17. Epub 2007 Nov 28. Review.


New complexities in helper T cell fate determination and the implications for autoimmune diseases.

Takatori H, Kanno Y, Chen Z, O'Shea JJ.

Mod Rheumatol. 2008;18(6):533-41. doi: 10.1007/s10165-008-0099-z. Epub 2008 Aug 5. Review.


T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C.

Immunity. 2008 Jan;28(1):29-39. doi: 10.1016/j.immuni.2007.11.016. Epub 2007 Dec 27.


IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state.

Nishihara M, Ogura H, Ueda N, Tsuruoka M, Kitabayashi C, Tsuji F, Aono H, Ishihara K, Huseby E, Betz UA, Murakami M, Hirano T.

Int Immunol. 2007 Jun;19(6):695-702. Epub 2007 May 9.


Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C.

Nature. 2007 Jul 26;448(7152):480-3. Epub 2007 Jun 20.


The T helper 17-regulatory T cell axis in transplant rejection and tolerance.

Mitchell P, Afzali B, Lombardi G, Lechler RI.

Curr Opin Organ Transplant. 2009 Aug;14(4):326-31. doi: 10.1097/MOT.0b013e32832ce88e. Review.


Th17 cells: a new fate for differentiating helper T cells.

Chen Z, O'Shea JJ.

Immunol Res. 2008;41(2):87-102. doi: 10.1007/s12026-007-8014-9. Review.


Regulation of T helper 17 differentiation by orphan nuclear receptors: it's not just ROR gamma t anymore.

Sundrud MS, Rao A.

Immunity. 2008 Jan;28(1):5-7. doi: 10.1016/j.immuni.2007.12.006.


A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.

Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M.

Eur J Immunol. 2009 Jul;39(7):1716-25. doi: 10.1002/eji.200939412.


The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells.

Crome SQ, Wang AY, Kang CY, Levings MK.

Eur J Immunol. 2009 Jun;39(6):1480-93. doi: 10.1002/eji.200838908.


Keeping autoimmunity in check: how to control a Th17 cell controller.

Nurieva RI, Dong C.

Immunity. 2008 Dec 19;29(6):841-3. doi: 10.1016/j.immuni.2008.12.001.


Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology.

van Hamburg JP, de Bruijn MJ, Ribeiro de Almeida C, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW.

Eur J Immunol. 2008 Sep;38(9):2573-86. doi: 10.1002/eji.200737840.


Signal transduction and Th17 cell differentiation.

O'Shea JJ, Steward-Tharp SM, Laurence A, Watford WT, Wei L, Adamson AS, Fan S.

Microbes Infect. 2009 Apr;11(5):599-611. doi: 10.1016/j.micinf.2009.04.007. Epub 2009 Apr 18. Review.


IFN-beta inhibits human Th17 cell differentiation.

Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S.

J Immunol. 2009 Oct 15;183(8):5418-27. doi: 10.4049/jimmunol.0803227. Epub 2009 Sep 25.


Regulation of IL-17 production in human lymphocytes.

Chen Z, O'Shea JJ.

Cytokine. 2008 Feb;41(2):71-8. Epub 2007 Nov 5. Review.


Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.

Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F.

Nat Immunol. 2007 Sep;8(9):942-9. Epub 2007 Aug 5.


Targeting the development and effector functions of TH17 cells.

Ghilardi N, Ouyang W.

Semin Immunol. 2007 Dec;19(6):383-93. Epub 2008 Jan 14. Review.


AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation.

Saito Y, Kagami S, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.

Arthritis Rheumatol. 2014 May;66(5):1185-94. doi: 10.1002/art.38324.


IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.

Wei L, Laurence A, Elias KM, O'Shea JJ.

J Biol Chem. 2007 Nov 30;282(48):34605-10. Epub 2007 Sep 20.

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