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IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.

Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA.

J Immunol. 2008 Jan 1;180(1):522-9.


Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.

Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR, Jackman J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Kauder SE, Toy K, Ha C, Modrusan Z, Wu LC, Collard HR, Wolters PJ, Egen JG, Arron JR.

J Immunol. 2014 Jul 1;193(1):111-9. doi: 10.4049/jimmunol.1301761. Epub 2014 May 30.


IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice.

Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA.

J Clin Invest. 2007 Oct;117(10):2941-51.


CXCR3 Requirement for the Interleukin-13-Mediated Up-Regulation of Interleukin-13Rα2 in Pulmonary Fibroblasts.

Barnes JC, Lumsden RV, Worrell J, Counihan IP, O'Beirne SL, Belperio JA, Fabre A, Donnelly SC, Boylan D, Kane R, Keane MP.

Am J Respir Cell Mol Biol. 2015 Aug;53(2):217-25. doi: 10.1165/rcmb.2013-0433OC.


In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.

Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT.

Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27.


Modulation of pulmonary fibrosis by IL-13Rα2.

Lumsden RV, Worrell JC, Boylan D, Walsh SM, Cramton J, Counihan I, O'Beirne S, Medina MF, Gauldie J, Fabre A, Donnelly SC, Kane R, Keane MP.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L710-8. doi: 10.1152/ajplung.00120.2014. Epub 2015 Feb 6.


IL-13-induced chemokine responses in the lung: role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling.

Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA.

J Immunol. 2002 Mar 15;168(6):2953-62.


Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 Pseudomonas exotoxin in pancreatic cancer therapy.

Shimamura T, Fujisawa T, Husain SR, Joshi B, Puri RK.

Clin Cancer Res. 2010 Jan 15;16(2):577-86. doi: 10.1158/1078-0432.CCR-09-2015. Epub 2010 Jan 12.


Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro.

Zheng T, Zhu Z, Liu W, Lee CG, Chen Q, Homer RJ, Elias JA.

J Allergy Clin Immunol. 2003 Apr;111(4):720-8.


Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.

Lee CG, Hartl D, Matsuura H, Dunlop FM, Scotney PD, Fabri LJ, Nash AD, Chen NY, Tang CY, Chen Q, Homer RJ, Baca M, Elias JA.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):739-46. doi: 10.1165/rcmb.2008-0053OC. Epub 2008 Jul 10.


IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.

Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA.

J Immunol. 2005 Feb 15;174(4):2305-13.


Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells.

Zhao Y, He D, Zhao J, Wang L, Leff AR, Spannhake EW, Georas S, Natarajan V.

J Biol Chem. 2007 Apr 6;282(14):10172-9. Epub 2007 Feb 6.


Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13.

Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide DH.

Respir Res. 2010 Nov 1;11:154. doi: 10.1186/1465-9921-11-154.


Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses.

Khodoun M, Lewis CC, Yang JQ, Orekov T, Potter C, Wynn T, Mentink-Kane M, Hershey GK, Wills-Karp M, Finkelman FD.

J Immunol. 2007 Nov 15;179(10):6429-38. Erratum in: J Immunol. 2008 Jan 1;180(1):664. Lewis, Christina [corrected to Lewis, Christina C].


Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis.

Madala SK, Dolan MA, Sharma D, Ramalingam TR, Wilson MS, Mentink-Kane MM, Masison DC, Wynn TA.

Proteins. 2011 Jan;79(1):282-93. doi: 10.1002/prot.22881.


Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways.

Lee CG, Homer RJ, Cohn L, Link H, Jung S, Craft JE, Graham BS, Johnson TR, Elias JA.

J Biol Chem. 2002 Sep 20;277(38):35466-74. Epub 2002 Jul 9.


The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

Andrews AL, Nordgren IK, Campbell-Harding G, Holloway JW, Holgate ST, Davies DE, Tavassoli A.

Mol Biosyst. 2013 Dec;9(12):3009-14. doi: 10.1039/c3mb70298g. Epub 2013 Sep 20.


The signaling function of the IL-13Ralpha2 receptor in the development of gastrointestinal fibrosis and cancer surveillance.

Strober W, Kitani A, Fichtner-Feigl S, Fuss IJ.

Curr Mol Med. 2009 Aug;9(6):740-50. Review.


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