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Items: 1 to 20 of 164


Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity.

Reckling S, Divanovic S, Karp CL, Wojciechowski S, Belkaid Y, Hildeman D.

Infect Immun. 2008 Mar;76(3):1179-85. Epub 2007 Dec 17.


Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory.

Wojciechowski S, Jordan MB, Zhu Y, White J, Zajac AJ, Hildeman DA.

Eur J Immunol. 2006 Jul;36(7):1694-706.


CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity.

Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL.

Nature. 2002 Dec 5;420(6915):502-7.


Preferential control of induced regulatory T cell homeostasis via a Bim/Bcl-2 axis.

Wang X, Szymczak-Workman AL, Gravano DM, Workman CJ, Green DR, Vignali DA.

Cell Death Dis. 2012 Feb 9;3:e270. doi: 10.1038/cddis.2012.9.


CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.

Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D.

J Immunol. 2002 Apr 15;168(8):3992-4000.


Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

Radwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, Arendse B, Kirsch R, Hunig T, Alexander J, Kaye P, Brombacher F.

PLoS Pathog. 2007 May 11;3(5):e68.


Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.

Tripathi P, Koss B, Opferman JT, Hildeman DA.

Cell Death Differ. 2013 Aug;20(8):998-1007. doi: 10.1038/cdd.2013.25. Epub 2013 Apr 5.


Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

Pagán AJ, Peters NC, Debrabant A, Ribeiro-Gomes F, Pepper M, Karp CL, Jenkins MK, Sacks DL.

Eur J Immunol. 2013 Feb;43(2):427-38. doi: 10.1002/eji.201242715. Epub 2012 Dec 11.


SDF-1α degrades whereas glycoprotein 120 upregulates Bcl-2 interacting mediator of death extralong isoform: implications for the development of T cell memory.

Trushin SA, Carena AA, Bren GD, Rizza SA, Dong X, Abraham RS, Badley AD.

J Immunol. 2012 Aug 15;189(4):1835-42. doi: 10.4049/jimmunol.1100275. Epub 2012 Jul 16.


IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection.

Anderson CF, Stumhofer JS, Hunter CA, Sacks D.

J Immunol. 2009 Oct 1;183(7):4619-27. doi: 10.4049/jimmunol.0804024. Epub 2009 Sep 11.


NF-kappa B1 is required for optimal CD4+ Th1 cell development and resistance to Leishmania major.

Artis D, Speirs K, Joyce K, Goldschmidt M, Caamaño J, Hunter CA, Scott P.

J Immunol. 2003 Feb 15;170(4):1995-2003.


Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

Mattner F, Magram J, Ferrante J, Launois P, Di Padova K, Behin R, Gately MK, Louis JA, Alber G.

Eur J Immunol. 1996 Jul;26(7):1553-9.


Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection.

Tabbara KS, Peters NC, Afrin F, Mendez S, Bertholet S, Belkaid Y, Sacks DL.

Infect Immun. 2005 Aug;73(8):4714-22.


Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia.

Pierce J, Rir-Sima-Ah J, Estrada I, Wilder J, Strasser A, Tesfaigzi Y.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L862-70. Epub 2006 Jun 16.


Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigen.

Hu QN, Baldwin TA.

J Immunol. 2015 Mar 15;194(6):2643-53. doi: 10.4049/jimmunol.1400030. Epub 2015 Feb 16.

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