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Items: 1 to 20 of 145


Coronavirus escape from heptad repeat 2 (HR2)-derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein.

Bosch BJ, Rossen JW, Bartelink W, Zuurveen SJ, de Haan CA, Duquerroy S, Boucher CA, Rottier PJ.

J Virol. 2008 Mar;82(5):2580-5. Epub 2007 Dec 12.


Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ.

Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8455-60. Epub 2004 May 18.


Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.

Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z.

Biochemistry. 2004 Nov 9;43(44):14064-71.


Structural basis for coronavirus-mediated membrane fusion. Crystal structure of mouse hepatitis virus spike protein fusion core.

Xu Y, Liu Y, Lou Z, Qin L, Li X, Bai Z, Pang H, Tien P, Gao GF, Rao Z.

J Biol Chem. 2004 Jul 16;279(29):30514-22. Epub 2004 Apr 27.


Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state.

Hakansson-McReynolds S, Jiang S, Rong L, Caffrey M.

J Biol Chem. 2006 Apr 28;281(17):11965-71. Epub 2006 Feb 28.


Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system.

Tsai JC, de Groot L, Pinon JD, Iacono KT, Phillips JJ, Seo SH, Lavi E, Weiss SR.

Virology. 2003 Aug 1;312(2):369-80.


Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core.

Xu Y, Lou Z, Liu Y, Pang H, Tien P, Gao GF, Rao Z.

J Biol Chem. 2004 Nov 19;279(47):49414-9. Epub 2004 Sep 1.


Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors.

Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK.

Antiviral Res. 2009 Jan;81(1):82-7. doi: 10.1016/j.antiviral.2008.10.001. Epub 2008 Nov 5.


Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein.

Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H.

Biochem Biophys Res Commun. 2004 Jul 2;319(3):746-52.


Core structure of S2 from the human coronavirus NL63 spike glycoprotein.

Zheng Q, Deng Y, Liu J, van der Hoek L, Berkhout B, Lu M.

Biochemistry. 2006 Dec 26;45(51):15205-15. Epub 2006 Dec 1.


Construct design, biophysical, and biochemical characterization of the fusion core from mouse hepatitis virus (a coronavirus) spike protein.

Xu Y, Cole DK, Lou Z, Liu Y, Qin L, Li X, Bai Z, Yuan F, Rao Z, Gao GF.

Protein Expr Purif. 2004 Nov;38(1):116-22.


Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.

Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF.

Biochem Biophys Res Commun. 2004 Jun 18;319(1):283-8.


Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.

Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S.

Lancet. 2004 Mar 20;363(9413):938-47.


Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.

Deng Y, Liu J, Zheng Q, Yong W, Lu M.

Structure. 2006 May;14(5):889-99.


Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain.

Ni L, Zhu J, Zhang J, Yan M, Gao GF, Tien P.

Biochem Biophys Res Commun. 2005 Apr 29;330(1):39-45.


Coronavirus-induced membrane fusion requires the cysteine-rich domain in the spike protein.

Chang KW, Sheng Y, Gombold JL.

Virology. 2000 Mar 30;269(1):212-24.

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