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Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.

Guillery O, Malka F, Landes T, Guillou E, Blackstone C, Lombès A, Belenguer P, Arnoult D, Rojo M.

Biol Cell. 2008 May;100(5):315-25.


Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization.

Möpert K, Hajek P, Frank S, Chen C, Kaufmann J, Santel A.

Exp Cell Res. 2009 Aug 1;315(13):2165-80. doi: 10.1016/j.yexcr.2009.04.016. Epub 2009 May 3.


Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage.

Griparic L, Kanazawa T, van der Bliek AM.

J Cell Biol. 2007 Aug 27;178(5):757-64. Epub 2007 Aug 20.


The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

Wai T, Saita S, Nolte H, Müller S, König T, Richter-Dennerlein R, Sprenger HG, Madrenas J, Mühlmeister M, Brandt U, Krüger M, Langer T.

EMBO Rep. 2016 Dec;17(12):1844-1856. Epub 2016 Oct 13.


Regulation of mitochondrial morphology through proteolytic cleavage of OPA1.

Ishihara N, Fujita Y, Oka T, Mihara K.

EMBO J. 2006 Jul 12;25(13):2966-77. Epub 2006 Jun 15.


OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria.

Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS.

Mol Biol Cell. 2007 Sep;18(9):3582-90. Epub 2007 Jul 5.


Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.

Ehses S, Raschke I, Mancuso G, Bernacchia A, Geimer S, Tondera D, Martinou JC, Westermann B, Rugarli EI, Langer T.

J Cell Biol. 2009 Dec 28;187(7):1023-36. doi: 10.1083/jcb.200906084.


Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.

Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B.

Cell. 2006 Jul 14;126(1):163-75.


The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T.

J Cell Biol. 2014 Mar 17;204(6):919-29. doi: 10.1083/jcb.201308006. Epub 2014 Mar 10.


Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells.

Head B, Griparic L, Amiri M, Gandre-Babbe S, van der Bliek AM.

J Cell Biol. 2009 Dec 28;187(7):959-66. doi: 10.1083/jcb.200906083.


OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.

Song Z, Chen H, Fiket M, Alexander C, Chan DC.

J Cell Biol. 2007 Aug 27;178(5):749-55. Epub 2007 Aug 20.


Loss of Yme1L perturbates mitochondrial dynamics.

Ruan Y, Li H, Zhang K, Jian F, Tang J, Song Z.

Cell Death Dis. 2013 Oct 31;4:e896. doi: 10.1038/cddis.2013.414.


A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis.

Pellegrini L, Scorrano L.

Cell Death Differ. 2007 Jul;14(7):1275-84. Epub 2007 Apr 20. Review.


Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.

Zhang K, Li H, Song Z.

EMBO Rep. 2014 May;15(5):576-85. doi: 10.1002/embr.201338240. Epub 2014 Apr 9.


Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA.

Herlan M, Vogel F, Bornhovd C, Neupert W, Reichert AS.

J Biol Chem. 2003 Jul 25;278(30):27781-8. Epub 2003 Apr 21.


Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.

An HJ, Cho G, Lee JO, Paik SG, Kim YS, Lee H.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13014-9. doi: 10.1073/pnas.1307170110. Epub 2013 Jul 22.


The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock.

Sanjuán Szklarz LK, Scorrano L.

Biochim Biophys Acta. 2012 Oct;1817(10):1886-93. doi: 10.1016/j.bbabio.2012.05.001. Epub 2012 May 8.


L-OPA1 regulates mitoflash biogenesis independently from membrane fusion.

Rosselin M, Santo-Domingo J, Bermont F, Giacomello M, Demaurex N.

EMBO Rep. 2017 Mar;18(3):451-463. doi: 10.15252/embr.201642931. Epub 2017 Feb 7.


Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.

Song Z, Ghochani M, McCaffery JM, Frey TG, Chan DC.

Mol Biol Cell. 2009 Aug;20(15):3525-32. doi: 10.1091/mbc.E09-03-0252. Epub 2009 May 28.

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