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Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.

Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS.

J Biol Chem. 2008 Feb 8;283(6):3465-75. Epub 2007 Dec 10.


The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.


Regulation of mTOR and cell growth in response to energy stress by REDD1.

Sofer A, Lei K, Johannessen CM, Ellisen LW.

Mol Cell Biol. 2005 Jul;25(14):5834-45.


Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1.

Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR.

J Nutr. 2015 Apr;145(4):708-13. doi: 10.3945/jn.114.207621. Epub 2015 Feb 25.


Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.

Genes Dev. 2008 Jan 15;22(2):239-51. doi: 10.1101/gad.1617608.


Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1.

Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR.

J Biol Chem. 2006 Dec 22;281(51):39128-34. Epub 2006 Oct 30.


cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP.

Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6.


Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.

Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E703-11. doi: 10.1152/ajpendo.00250.2014. Epub 2014 Aug 26.


Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr.

Genes Dev. 2004 Dec 1;18(23):2893-904. Epub 2004 Nov 15.


Acute alcohol intoxication increases REDD1 in skeletal muscle.

Lang CH, Frost RA, Vary TC.

Alcohol Clin Exp Res. 2008 May;32(5):796-805. doi: 10.1111/j.1530-0277.2008.00637.x. Epub 2008 Mar 11.


PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.

J Biol Chem. 2014 Oct 24;289(43):29739-49. doi: 10.1074/jbc.M114.584821. Epub 2014 Aug 27.


Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.

Sato T, Umetsu A, Tamanoi F.

Methods Enzymol. 2008;438:307-20. doi: 10.1016/S0076-6879(07)38021-X.


Hypoxia-induced energy stress regulates mRNA translation and cell growth.

Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC.

Mol Cell. 2006 Feb 17;21(4):521-31.


Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.

McGhee NK, Jefferson LS, Kimball SR.

J Nutr. 2009 May;139(5):828-34. doi: 10.3945/jn.108.099846. Epub 2009 Mar 18.


Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle.

Murakami T, Hasegawa K, Yoshinaga M.

Biochem Biophys Res Commun. 2011 Feb 25;405(4):615-9. doi: 10.1016/j.bbrc.2011.01.078. Epub 2011 Jan 25.


REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Dennis MD, Coleman CS, Berg A, Jefferson LS, Kimball SR.

Sci Signal. 2014 Jul 22;7(335):ra68. doi: 10.1126/scisignal.2005103. Erratum in: Sci Signal. 2015 Mar 17;8(368):er4.


Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.

J Biol Chem. 2008 Nov 7;283(45):30482-92. doi: 10.1074/jbc.M803348200. Epub 2008 Aug 1.

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