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Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.

Xu Y, Ikegami M, Wang Y, Matsuzaki Y, Whitsett JA.

BMC Genomics. 2007 Dec 10;8:455.


STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells.

Matsuzaki Y, Besnard V, Clark JC, Xu Y, Wert SE, Ikegami M, Whitsett JA.

Am J Respir Cell Mol Biol. 2008 May;38(5):551-8. Epub 2007 Dec 20.


STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.

Ikegami M, Falcone A, Whitsett JA.

J Appl Physiol (1985). 2008 Jun;104(6):1753-60. doi: 10.1152/japplphysiol.00875.2007. Epub 2008 Mar 27.


C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.

Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, Ikegami M.

Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L286-98. doi: 10.1152/ajplung.00094.2009. Epub 2009 May 22.


Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.

Matsuzaki Y, Xu Y, Ikegami M, Besnard V, Park KS, Hull WM, Wert SE, Whitsett JA.

J Immunol. 2006 Jul 1;177(1):527-37.


Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.

Bridges JP, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, Whitsett JA, Xu Y.

PLoS One. 2014 May 7;9(5):e91376. doi: 10.1371/journal.pone.0091376. eCollection 2014.


Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung.

Pathak RR, Grover A, Malaney P, Quarni W, Pandit A, Allen-Gipson D, Davé V.

J Biol Chem. 2013 Oct 11;288(41):29821-35. doi: 10.1074/jbc.M113.481523. Epub 2013 Aug 20.


The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

Clarkson RW, Boland MP, Kritikou EA, Lee JM, Freeman TC, Tiffen PG, Watson CJ.

Mol Endocrinol. 2006 Mar;20(3):675-85. Epub 2005 Nov 17.


Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.

Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA.

J Biol Chem. 2009 Feb 6;284(6):4018-30. doi: 10.1074/jbc.M805388200. Epub 2008 Dec 11.


Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development.

Ebong S, Chepelinsky AB, Robinson ML, Zhao H, Yu CR, Egwuagu CE.

Mol Vis. 2004 Feb 19;10:122-31.


Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.

Plantier L, Besnard V, Xu Y, Ikegami M, Wert SE, Hunt AN, Postle AD, Whitsett JA.

J Biol Chem. 2012 Mar 23;287(13):10099-114. doi: 10.1074/jbc.M111.303669. Epub 2012 Jan 20.


Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size.

Bridges JP, Ludwig MG, Mueller M, Kinzel B, Sato A, Xu Y, Whitsett JA, Ikegami M.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):348-57. doi: 10.1165/rcmb.2012-0439OC.


Deletion of STK40 protein in mice causes respiratory failure and death at birth.

Yu H, He K, Li L, Sun L, Tang F, Li R, Ning W, Jin Y.

J Biol Chem. 2013 Feb 22;288(8):5342-52. doi: 10.1074/jbc.M112.409433. Epub 2013 Jan 4.


Prevention of trauma/hemorrhagic shock-induced lung apoptosis by IL-6-mediated activation of Stat3.

Moran A, Tsimelzon AI, Mastrangelo MA, Wu Y, Yu B, Hilsenbeck SG, Poli V, Tweardy DJ.

Clin Transl Sci. 2009 Feb;2(1):41-9. doi: 10.1111/j.1752-8062.2008.00076.x.


Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach.

Jiang K, Krous LC, Knowlton N, Chen Y, Frank MB, Cadwell C, Centola M, Jarvis JN.

Placenta. 2009 Sep;30(9):806-15. doi: 10.1016/j.placenta.2009.06.006. Epub 2009 Jul 18.


Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis.

Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH.

Am J Respir Crit Care Med. 2010 Feb 1;181(3):254-63. doi: 10.1164/rccm.200810-1615OC. Epub 2009 Oct 22.


Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia inhibitory factor.

Chen Y, Deng J, Fujimoto J, Kadara H, Men T, Lotan D, Lotan R.

Cancer Res. 2010 Nov 1;70(21):8917-26. doi: 10.1158/0008-5472.CAN-10-0518. Epub 2010 Oct 19.

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