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Items: 1 to 20 of 209

1.

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.

Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL, Travis WD, Bornmann W, Veach D, Clarkson B, Bromberg JF.

J Clin Invest. 2007 Dec;117(12):3846-56.

2.

IL-6 involvement in epithelial cancers.

Schafer ZT, Brugge JS.

J Clin Invest. 2007 Dec;117(12):3660-3.

3.

Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer.

Berishaj M, Gao SP, Ahmed S, Leslie K, Al-Ahmadie H, Gerald WL, Bornmann W, Bromberg JF.

Breast Cancer Res. 2007;9(3):R32.

4.

Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer.

Haura EB, Zheng Z, Song L, Cantor A, Bepler G.

Clin Cancer Res. 2005 Dec 1;11(23):8288-94.

5.

JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling.

Song L, Rawal B, Nemeth JA, Haura EB.

Mol Cancer Ther. 2011 Mar;10(3):481-94. doi: 10.1158/1535-7163.MCT-10-0502. Epub 2011 Jan 7.

6.

Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation.

Leslie K, Gao SP, Berishaj M, Podsypanina K, Ho H, Ivashkiv L, Bromberg J.

Breast Cancer Res. 2010;12(5):R80. doi: 10.1186/bcr2725. Epub 2010 Oct 7.

7.

STAT3 expression in activating EGFR-driven adenocarcinoma of the lung.

Takata S, Takigawa N, Segawa Y, Kubo T, Ohashi K, Kozuki T, Teramoto N, Yamashita M, Toyooka S, Tanimoto M, Kiura K.

Lung Cancer. 2012 Jan;75(1):24-9. doi: 10.1016/j.lungcan.2011.05.015.

PMID:
21684622
8.

Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells.

Cao W, Liu Y, Zhang R, Zhang B, Wang T, Zhu X, Mei L, Chen H, Zhang H, Ming P, Huang L.

Sci Rep. 2015 Jul 13;5:8477. doi: 10.1038/srep08477.

9.

The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer.

Zhang N, Zeng Y, Du W, Zhu J, Shen D, Liu Z, Huang JA.

Int J Oncol. 2016 Oct;49(4):1360-8. doi: 10.3892/ijo.2016.3632. Epub 2016 Jul 26.

PMID:
27499357
10.

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

Chaib I, Karachaliou N, Pilotto S, Codony Servat J, Cai X, Li X, Drozdowskyj A, Servat CC, Yang J, Hu C, Cardona AF, Vivanco GL, Vergnenegre A, Sanchez JM, Provencio M, de Marinis F, Passaro A, Carcereny E, Reguart N, Campelo CG, Teixido C, Sperduti I, Rodriguez S, Lazzari C, Verlicchi A, de Aguirre I, Queralt C, Wei J, Estrada R, Puig de la Bellacasa R, Ramirez JL, Jacobson K, Ditzel HJ, Santarpia M, Viteri S, Molina MA, Zhou C, Cao P, Ma PC, Bivona TG, Rosell R.

J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx014.

11.

Activation of the signal transducer and activator of transcription 3 pathway up-regulates estrogen receptor-beta expression in lung adenocarcinoma cells.

Wang HC, Yeh HH, Huang WL, Lin CC, Su WP, Chen HH, Lai WW, Su WC.

Mol Endocrinol. 2011 Jul;25(7):1145-58. doi: 10.1210/me.2010-0495. Epub 2011 May 5.

12.

p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway.

Ozenne P, Dayde D, Brambilla E, Eymin B, Gazzeri S.

Oncogene. 2013 Feb 21;32(8):1050-8. doi: 10.1038/onc.2012.107. Epub 2012 Mar 26.

PMID:
22450744
13.

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor.

Wang Y, van Boxel-Dezaire AH, Cheon H, Yang J, Stark GR.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16975-80. doi: 10.1073/pnas.1315862110. Epub 2013 Sep 30.

15.

Activation of the AKT and STAT3 pathways and prolonged survival by a mutant EGFR in human lung cancer cells.

Akca H, Tani M, Hishida T, Matsumoto S, Yokota J.

Lung Cancer. 2006 Oct;54(1):25-33. Epub 2006 Jul 26.

PMID:
16872715
17.

STAT3 can be activated through paracrine signaling in breast epithelial cells.

Lieblein JC, Ball S, Hutzen B, Sasser AK, Lin HJ, Huang TH, Hall BM, Lin J.

BMC Cancer. 2008 Oct 21;8:302. doi: 10.1186/1471-2407-8-302.

18.

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model.

Murakami T, Takigawa N, Ninomiya T, Ochi N, Yasugi M, Honda Y, Kubo T, Ichihara E, Hotta K, Tanimoto M, Kiura K.

Lung Cancer. 2014 Jan;83(1):30-6. doi: 10.1016/j.lungcan.2013.10.011. Epub 2013 Oct 29.

19.

IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.

Zhang X, Yin P, DI D, Luo G, Zheng L, Wei J, Zhang J, Shi Y, Zhang J, Xu N.

Anticancer Res. 2009 Nov;29(11):4497-501.

20.

STAT3 negatively regulates thyroid tumorigenesis.

Couto JP, Daly L, Almeida A, Knauf JA, Fagin JA, Sobrinho-Simões M, Lima J, Máximo V, Soares P, Lyden D, Bromberg JF.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2361-70. doi: 10.1073/pnas.1201232109. Epub 2012 Aug 13.

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