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Items: 1 to 20 of 106

1.

Input DNA ratio determines copy number of the 33 kb Factor IX gene on de novo human artificial chromosomes.

Breman AM, Steiner CM, Slee RB, Grimes BR.

Mol Ther. 2008 Feb;16(2):315-23. Epub 2007 Dec 4.

2.

Efficient assembly of de novo human artificial chromosomes from large genomic loci.

Basu J, Compitello G, Stromberg G, Willard HF, Van Bokkelen G.

BMC Biotechnol. 2005 Jul 5;5:21.

3.

Escherichia coli-cloned CFTR loci relevant for human artificial chromosome therapy.

Rocchi L, Braz C, Cattani S, Ramalho A, Christan S, Edlinger M, Ascenzioni F, Laner A, Kraner S, Amaral M, Schindelhauer D.

Hum Gene Ther. 2010 Sep;21(9):1077-92. doi: 10.1089/hum.2009.225.

PMID:
20384480
4.

Functional complementation of a genetic deficiency with human artificial chromosomes.

Mejía JE, Willmott A, Levy E, Earnshaw WC, Larin Z.

Am J Hum Genet. 2001 Aug;69(2):315-26. Epub 2001 Jul 10.

5.

Construction of human artificial chromosome vectors by recombineering.

Kotzamanis G, Cheung W, Abdulrazzak H, Perez-Luz S, Howe S, Cooke H, Huxley C.

Gene. 2005 May 23;351:29-38. Epub 2005 Apr 15.

PMID:
15837432
6.
7.

Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M.

DNA Res. 2010 Oct;17(5):293-301. doi: 10.1093/dnares/dsq020. Epub 2010 Aug 26.

8.

Stable maintenance of de novo assembled human artificial chromosomes in embryonic stem cells and their differentiated progeny in mice.

Liskovykh M, Ponomartsev S, Popova E, Bader M, Kouprina N, Larionov V, Alenina N, Tomilin A.

Cell Cycle. 2015;14(8):1268-73. doi: 10.1080/15384101.2015.1014151.

9.

Stable gene expression from a mammalian artificial chromosome.

Grimes BR, Schindelhauer D, McGill NI, Ross A, Ebersole TA, Cooke HJ.

EMBO Rep. 2001 Oct;2(10):910-4. Epub 2001 Sep 24.

10.

A novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21.

Miyamoto K, Suzuki N, Sakai K, Asakawa S, Okazaki T, Kudoh J, Ikeno M, Shimizu N.

Transgenic Res. 2014 Apr;23(2):317-29. doi: 10.1007/s11248-013-9772-x. Epub 2013 Nov 30.

PMID:
24293126
11.

Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment.

Vadolas J, Wardan H, Bosmans M, Zaibak F, Jamsai D, Voullaire L, Williamson R, Ioannou PA.

Biochim Biophys Acta. 2005 May 1;1728(3):150-62. Epub 2005 Mar 17.

PMID:
15820143
12.

Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host.

Poller W, Schneider-Rasp S, Liebert U, Merklein F, Thalheimer P, Haack A, Schwaab R, Schmitt C, Brackmann HH.

Gene Ther. 1996 Jun;3(6):521-30.

PMID:
8789802
14.

Integration-free and stable expression of FVIII using a human artificial chromosome.

Kurosaki H, Hiratsuka M, Imaoka N, Iida Y, Uno N, Kazuki Y, Ishihara C, Yakura Y, Mimuro J, Sakata Y, Takeya H, Oshimura M.

J Hum Genet. 2011 Oct;56(10):727-33. doi: 10.1038/jhg.2011.88. Epub 2011 Aug 11.

PMID:
21833006
15.

Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression.

Chandler KJ, Chandler RL, Broeckelmann EM, Hou Y, Southard-Smith EM, Mortlock DP.

Mamm Genome. 2007 Oct;18(10):693-708. Epub 2007 Sep 20.

16.

Developing de novo human artificial chromosomes in embryonic stem cells using HSV-1 amplicon technology.

Moralli D, Monaco ZL.

Chromosome Res. 2015 Feb;23(1):105-10. doi: 10.1007/s10577-014-9456-2. Review.

17.

Bacterial transfer of large functional genomic DNA into human cells.

Laner A, Goussard S, Ramalho AS, Schwarz T, Amaral MD, Courvalin P, Schindelhauer D, Grillot-Courvalin C.

Gene Ther. 2005 Nov;12(21):1559-72.

PMID:
15973438
18.
19.

A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning.

Ayabe F, Katoh M, Inoue T, Kouprina N, Larionov V, Oshimura M.

J Hum Genet. 2005;50(11):592-9. Epub 2005 Oct 18.

PMID:
16231070
20.

A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector.

Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M, Ohbayashi T.

PLoS One. 2011 Feb 24;6(2):e17267. doi: 10.1371/journal.pone.0017267.

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