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Items: 1 to 20 of 68

1.

New rationales for using TGFbeta inhibitors in radiotherapy.

Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH.

Int J Radiat Biol. 2007 Nov-Dec;83(11-12):803-11. Review.

PMID:
18058368
2.

Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.

Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH.

Cancer Res. 2006 Nov 15;66(22):10861-9. Epub 2006 Nov 6.

3.

Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.

Veuger SJ, Durkacz BW.

DNA Repair (Amst). 2011 Feb 7;10(2):235-44. doi: 10.1016/j.dnarep.2010.11.005. Epub 2010 Dec 8.

PMID:
21144805
4.

TGFbeta-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling.

Wiegman EM, Blaese MA, Loeffler H, Coppes RP, Rodemann HP.

Radiother Oncol. 2007 Jun;83(3):289-95. Epub 2007 Jun 8.

PMID:
17560675
5.

Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.

Mori Y, Ishida W, Bhattacharyya S, Li Y, Platanias LC, Varga J.

Arthritis Rheum. 2004 Dec;50(12):4008-21.

6.

Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.

Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK.

Cancer Res. 2007 Apr 1;67(7):3010-7.

7.
8.

ATM as a target for novel radiosensitizers.

Sarkaria JN, Eshleman JS.

Semin Radiat Oncol. 2001 Oct;11(4):316-27. Review.

PMID:
11677656
9.

Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.

Fan JR, Huang TH, Wen CY, Shen TL, Li TK.

Eur J Pharmacol. 2010 Jul 25;638(1-3):13-20. doi: 10.1016/j.ejphar.2010.04.012. Epub 2010 Apr 18.

PMID:
20406630
10.

Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.

Akool el-S, Doller A, Müller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W.

J Biol Chem. 2005 Nov 25;280(47):39403-16. Epub 2005 Sep 23.

11.

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.

Lavin MF, Khanna KK.

Int J Radiat Biol. 1999 Oct;75(10):1201-14. Review.

PMID:
10549596
12.

D-501036, a novel selenophene-based triheterocycle derivative, exhibits potent in vitro and in vivo antitumoral activity which involves DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation.

Juang SH, Lung CC, Hsu PC, Hsu KS, Li YC, Hong PC, Shiah HS, Kuo CC, Huang CW, Wang YC, Huang L, Chen TS, Chen SF, Fu KC, Hsu CL, Lin MJ, Chang CJ, Ashendel CL, Chan TC, Chou KM, Chang JY.

Mol Cancer Ther. 2007 Jan;6(1):193-202.

13.

Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein.

Li W, Jian W, Xiaoping X, Yingfeng L, Tao X, Xiaoyan X.

Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1620-30.

PMID:
16884376
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17.

Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.

Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, Singh G, Wright J, Tsakiridis T.

Int J Radiat Oncol Biol Phys. 2010 Sep 1;78(1):221-9. doi: 10.1016/j.ijrobp.2010.03.005. Epub 2010 Jul 7.

PMID:
20615625
18.

Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2.

Kool J, Hamdi M, Cornelissen-Steijger P, van der Eb AJ, Terleth C, van Dam H.

Oncogene. 2003 Jul 3;22(27):4235-42.

PMID:
12833146
19.

ATM localization and gene expression in the adult mouse eye.

Leemput J, Masson C, Bigot K, Errachid A, Dansault A, Provost A, Gadin S, Aoufouchi S, Menasche M, Abitbol M.

Mol Vis. 2009;15:393-416. Epub 2009 Feb 20.

20.

The role of ATM in DNA damage responses and cancer.

Canman CE, Lim DS.

Oncogene. 1998 Dec 24;17(25):3301-8. Review.

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