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Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.

van der Merwe M, Bjornsti MA.

J Biol Chem. 2008 Feb 8;283(6):3305-15. Epub 2007 Dec 4.


Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.

Losasso C, Cretaio E, Palle K, Pattarello L, Bjornsti MA, Benedetti P.

J Biol Chem. 2007 Mar 30;282(13):9855-64. Epub 2007 Feb 2.


Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

Fiorani P, Amatruda JF, Silvestri A, Butler RH, Bjornsti MA, Benedetti P.

Mol Pharmacol. 1999 Dec;56(6):1105-15.


Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.

Colley WC, van der Merwe M, Vance JR, Burgin AB Jr, Bjornsti MA.

J Biol Chem. 2004 Dec 24;279(52):54069-78. Epub 2004 Oct 15.


Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.

Woo MH, Vance JR, Marcos AR, Bailly C, Bjornsti MA.

J Biol Chem. 2002 Feb 8;277(6):3813-22. Epub 2001 Dec 3.


DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.

Wright CM, van der Merwe M, DeBrot AH, Bjornsti MA.

J Biol Chem. 2015 May 8;290(19):12068-78. doi: 10.1074/jbc.M114.635078. Epub 2015 Mar 20.


Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.

Fiorani P, Bruselles A, Falconi M, Chillemi G, Desideri A, Benedetti P.

J Biol Chem. 2003 Oct 31;278(44):43268-75. Epub 2003 Aug 6.


Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae.

Fiorani P, Bjornsti MA.

Ann N Y Acad Sci. 2000;922:65-75. Review.


Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.

Tesauro C, Morozzo della Rocca B, Ottaviani A, Coletta A, Zuccaro L, Arnò B, D'Annessa I, Fiorani P, Desideri A.

Mol Cancer. 2013 Sep 3;12(1):100. doi: 10.1186/1476-4598-12-100.


A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance.

Losasso C, Cretaio E, Fiorani P, D'Annessa I, Chillemi G, Benedetti P.

Nucleic Acids Res. 2008 Oct;36(17):5635-44. doi: 10.1093/nar/gkn557. Epub 2008 Sep 4.


Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA.

Hann CL, Carlberg AL, Bjornsti MA.

J Biol Chem. 1998 Nov 20;273(47):31519-27.


Mutation of Gly717Phe in human topoisomerase 1B has an effect on enzymatic function, reactivity to the camptothecin anticancer drug and on the linker domain orientation.

Wang Z, D'Annessa I, Tesauro C, Croce S, Ottaviani A, Fiorani P, Desideri A.

Biochim Biophys Acta. 2015 Aug;1854(8):860-8. doi: 10.1016/j.bbapap.2015.04.017. Epub 2015 Apr 22.


The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation.

D'Annessa I, Tesauro C, Wang Z, Arnò B, Zuccaro L, Fiorani P, Desideri A.

Biochim Biophys Acta. 2013 Dec;1834(12):2712-21. doi: 10.1016/j.bbapap.2013.09.017. Epub 2013 Oct 2.


Domains of human topoisomerase I and associated functions.

Champoux JJ.

Prog Nucleic Acid Res Mol Biol. 1998;60:111-32. Review.


Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.

Fan Y, Weinstein JN, Kohn KW, Shi LM, Pommier Y.

J Med Chem. 1998 Jun 18;41(13):2216-26.


Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

Woo MH, Losasso C, Guo H, Pattarello L, Benedetti P, Bjornsti MA.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13767-72. Epub 2003 Oct 29.


Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.

Palle K, Pattarello L, van der Merwe M, Losasso C, Benedetti P, Bjornsti MA.

J Biol Chem. 2008 Oct 10;283(41):27767-75. doi: 10.1074/jbc.M804826200. Epub 2008 Aug 8.


Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance.

Diaz-González R, Pérez-Pertejo Y, Pommier Y, Balaña-Fouce R, Reguera RM.

Biochem Pharmacol. 2008 Sep 1;76(5):608-19. doi: 10.1016/j.bcp.2008.06.019. Epub 2008 Jul 4.


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