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Items: 1 to 20 of 156

1.
3.

Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells.

Arisan ED, Kutuk O, Tezil T, Bodur C, Telci D, Basaga H.

Breast Cancer Res Treat. 2010 Jan;119(2):271-81. doi: 10.1007/s10549-009-0343-z. Epub 2009 Feb 24.

PMID:
19238538
6.

Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells.

Simonin K, Brotin E, Dufort S, Dutoit S, Goux D, N'diaye M, Denoyelle C, Gauduchon P, Poulain L.

Mol Cancer Ther. 2009 Nov;8(11):3162-70. doi: 10.1158/1535-7163.MCT-09-0493. Epub 2009 Nov 3.

8.

Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells.

Jin CY, Park C, Lee JH, Chung KT, Kwon TK, Kim GY, Choi BT, Choi YH.

Toxicol In Vitro. 2009 Mar;23(2):259-65. doi: 10.1016/j.tiv.2008.12.005. Epub 2008 Dec 16.

PMID:
19124070
9.

Effect of HA14-1 on apoptosis-regulating proteins in HeLa cells.

Rehman K, Tariq M, Akash MS, Gillani Z, Qazi MH.

Chem Biol Drug Des. 2014 Mar;83(3):317-23. doi: 10.1111/cbdd.12245. Epub 2013 Dec 26.

PMID:
24118733
11.

Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.

Hermanson D, Addo SN, Bajer AA, Marchant JS, Das SG, Srinivasan B, Al-Mousa F, Michelangeli F, Thomas DD, Lebien TW, Xing C.

Mol Pharmacol. 2009 Sep;76(3):667-78. doi: 10.1124/mol.109.055830. Epub 2009 Jun 26.

12.

Combination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expression.

Wong FY, Liem N, Xie C, Yan FL, Wong WC, Wang L, Yong WP.

PLoS One. 2012;7(12):e50786. doi: 10.1371/journal.pone.0050786. Epub 2012 Dec 4.

13.

Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.

Tumilasci VF, Olière S, Nguyên TL, Shamy A, Bell J, Hiscott J.

J Virol. 2008 Sep;82(17):8487-99. doi: 10.1128/JVI.00851-08. Epub 2008 Jun 25.

14.

Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells.

Ranjan K, Sharma A, Surolia A, Pathak C.

Biofactors. 2014 Jan-Feb;40(1):157-69. doi: 10.1002/biof.1098. Epub 2013 Apr 5.

PMID:
23559532
15.

Upregulation of Death Receptor 5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate Cancer Cells to TRAIL Induced Apoptosis by Vitisin A.

Shin D, Kwon HY, Sohn EJ, Nam MS, Kim JH, Lee JC, Ryu SY, Park B, Kim SH.

Cell Physiol Biochem. 2015;36(3):1151-62. doi: 10.1159/000430286. Epub 2015 Jun 25.

17.

Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance.

van Oosterwijk JG, Herpers B, Meijer D, Briaire-de Bruijn IH, Cleton-Jansen AM, Gelderblom H, van de Water B, Bovée JV.

Ann Oncol. 2012 Jun;23(6):1617-26. doi: 10.1093/annonc/mdr512. Epub 2011 Nov 23.

PMID:
22112972
18.

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak.

Pérez-Galán P, Roué G, Villamor N, Campo E, Colomer D.

Blood. 2007 May 15;109(10):4441-9. Epub 2007 Jan 16.

20.

Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids.

Yang TM, Barbone D, Fennell DA, Broaddus VC.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):14-23. doi: 10.1165/rcmb.2008-0320OC. Epub 2008 Dec 18.

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