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Items: 1 to 20 of 252

1.

A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice.

Jiao P, Tian G, Li Y, Deng G, Jiang Y, Liu C, Liu W, Bu Z, Kawaoka Y, Chen H.

J Virol. 2008 Feb;82(3):1146-54. Epub 2007 Nov 21. Erratum in: J Virol. 2008 Apr;82(8):4190.

2.

Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein.

Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, Wolff T.

J Virol. 2010 Oct;84(20):10708-18. doi: 10.1128/JVI.00610-10. Epub 2010 Aug 4.

3.

Effect on virulence and pathogenicity of H5N1 influenza A virus through truncations of NS1 eIF4GI binding domain.

Zhou H, Zhu J, Tu J, Zou W, Hu Y, Yu Z, Yin W, Li Y, Zhang A, Wu Y, Yu Z, Chen H, Jin M.

J Infect Dis. 2010 Nov 1;202(9):1338-46. doi: 10.1086/656536.

PMID:
20854176
4.

The NS1 gene contributes to the virulence of H5N1 avian influenza viruses.

Li Z, Jiang Y, Jiao P, Wang A, Zhao F, Tian G, Wang X, Yu K, Bu Z, Chen H.

J Virol. 2006 Nov;80(22):11115-23. Epub 2006 Sep 13.

5.

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2.

Li J, Ishaq M, Prudence M, Xi X, Hu T, Liu Q, Guo D.

Virus Res. 2009 Sep;144(1-2):123-9. doi: 10.1016/j.virusres.2009.04.008. Epub 2009 Apr 23.

PMID:
19393699
6.

Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses.

Lipatov AS, Andreansky S, Webby RJ, Hulse DJ, Rehg JE, Krauss S, Perez DR, Doherty PC, Webster RG, Sangster MY.

J Gen Virol. 2005 Apr;86(Pt 4):1121-30.

PMID:
15784906
7.

Genetic compatibility and virulence of reassortants derived from contemporary avian H5N1 and human H3N2 influenza A viruses.

Chen LM, Davis CT, Zhou H, Cox NJ, Donis RO.

PLoS Pathog. 2008 May 23;4(5):e1000072. doi: 10.1371/journal.ppat.1000072.

8.

Synergism of co-mutation of two amino acid residues in NS1 protein increases the pathogenicity of influenza virus in mice.

Pu J, Wang J, Zhang Y, Fu G, Bi Y, Sun Y, Liu J.

Virus Res. 2010 Aug;151(2):200-4. doi: 10.1016/j.virusres.2010.05.007. Epub 2010 May 28.

PMID:
20546807
9.

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice.

Feng X, Wang Z, Shi J, Deng G, Kong H, Tao S, Li C, Liu L, Guan Y, Chen H.

J Virol. 2015 Dec 9;90(4):1872-9. doi: 10.1128/JVI.02387-15.

10.

The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice.

Hu J, Hu Z, Song Q, Gu M, Liu X, Wang X, Hu S, Chen C, Liu H, Liu W, Chen S, Peng D, Liu X.

J Virol. 2013 Mar;87(5):2660-72. doi: 10.1128/JVI.02891-12. Epub 2012 Dec 19.

11.

Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice.

Fan S, Deng G, Song J, Tian G, Suo Y, Jiang Y, Guan Y, Bu Z, Kawaoka Y, Chen H.

Virology. 2009 Feb 5;384(1):28-32. doi: 10.1016/j.virol.2008.11.044. Epub 2008 Dec 30.

12.

Molecular Determinants of Virulence and Stability of a Reporter-Expressing H5N1 Influenza A Virus.

Zhao D, Fukuyama S, Yamada S, Lopes TJ, Maemura T, Katsura H, Ozawa M, Watanabe S, Neumann G, Kawaoka Y.

J Virol. 2015 Nov;89(22):11337-46. doi: 10.1128/JVI.01886-15. Epub 2015 Sep 2.

13.

Effect of gene constellation and postreassortment amino acid change on the phenotypic features of H5 influenza virus reassortants.

Rudneva IA, Timofeeva TA, Shilov AA, Kochergin-Nikitsky KS, Varich NL, Ilyushina NA, Gambaryan AS, Krylov PS, Kaverin NV.

Arch Virol. 2007;152(6):1139-45. Epub 2007 Feb 9.

PMID:
17294090
14.

Inhibition of host innate immune responses and pathogenicity of recombinant Newcastle disease viruses expressing NS1 genes of influenza A viruses.

Kim SH, Samal SK.

J Gen Virol. 2010 Aug;91(Pt 8):1996-2001. doi: 10.1099/vir.0.021766-0. Epub 2010 Apr 21.

PMID:
20410312
15.

NP body domain and PB2 contribute to increased virulence of H5N1 highly pathogenic avian influenza viruses in chickens.

Tada T, Suzuki K, Sakurai Y, Kubo M, Okada H, Itoh T, Tsukamoto K.

J Virol. 2011 Feb;85(4):1834-46. doi: 10.1128/JVI.01648-10. Epub 2010 Dec 1.

16.

Genetic characterization of nonstructural genes of H5N1 avian influenza viruses isolated in Thailand in 2004-2005.

Suwannakhon N, Pookorn S, Sanguansermsri D, Chamnanpood C, Chamnanpood P, Wongvilairat R, Pongcharoen S, Niumsup PR, Kunthalert D, Sanguansermsri P.

Southeast Asian J Trop Med Public Health. 2008 Sep;39(5):837-47.

PMID:
19058578
17.

A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens.

Zhu Q, Yang H, Chen W, Cao W, Zhong G, Jiao P, Deng G, Yu K, Yang C, Bu Z, Kawaoka Y, Chen H.

J Virol. 2008 Jan;82(1):220-8. Epub 2007 Oct 17.

18.

Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice.

Rolling T, Koerner I, Zimmermann P, Holz K, Haller O, Staeheli P, Kochs G.

J Virol. 2009 Jul;83(13):6673-80. doi: 10.1128/JVI.00212-09. Epub 2009 Apr 29.

19.

Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence.

Li C, Hatta M, Nidom CA, Muramoto Y, Watanabe S, Neumann G, Kawaoka Y.

Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4687-92. doi: 10.1073/pnas.0912807107. Epub 2010 Feb 22.

20.

Recent H5N1 avian influenza A virus increases rapidly in virulence to mice after a single passage in mice.

Mase M, Tanimura N, Imada T, Okamatsu M, Tsukamoto K, Yamaguchi S.

J Gen Virol. 2006 Dec;87(Pt 12):3655-9.

PMID:
17098982

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