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Items: 1 to 20 of 96

1.
2.

The covalent modification and regulation of TLR8 in HEK-293 cells stimulated with imidazoquinoline agonists.

Rajagopal R, Waller AS, Mendoza JD, Wightman PD.

Biochem J. 2008 Jan 1;409(1):275-87.

PMID:
17868034
3.

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.

Philbin VJ, Dowling DJ, Gallington LC, Cortés G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O.

J Allergy Clin Immunol. 2012 Jul;130(1):195-204.e9. doi: 10.1016/j.jaci.2012.02.042. Epub 2012 Apr 21.

4.

Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines.

Gorden KK, Qiu X, Battiste JJ, Wightman PP, Vasilakos JP, Alkan SS.

J Immunol. 2006 Dec 1;177(11):8164-70.

5.

Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8.

Lan T, Kandimalla ER, Yu D, Bhagat L, Li Y, Wang D, Zhu F, Tang JX, Putta MR, Cong Y, Trombino AF, Sullivan T, Agrawal S.

Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13750-5. Epub 2007 Aug 14.

6.

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8.

Janke M, Poth J, Wimmenauer V, Giese T, Coch C, Barchet W, Schlee M, Hartmann G.

J Allergy Clin Immunol. 2009 May;123(5):1026-33. doi: 10.1016/j.jaci.2009.02.015. Epub 2009 Apr 10.

PMID:
19361845
7.

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O.

PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4.

8.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O.

PLoS One. 2015 Aug 14;10(8):e0134640. doi: 10.1371/journal.pone.0134640. eCollection 2015.

9.

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.

Doyle SL, Jefferies CA, Feighery C, O'Neill LA.

J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11.

10.

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses.

Forsbach A, Nemorin JG, Montino C, Müller C, Samulowitz U, Vicari AP, Jurk M, Mutwiri GK, Krieg AM, Lipford GB, Vollmer J.

J Immunol. 2008 Mar 15;180(6):3729-38.

11.

Synthetic agonists of Toll-like receptors 7, 8 and 9.

Agrawal S, Kandimalla ER.

Biochem Soc Trans. 2007 Dec;35(Pt 6):1461-7. Review.

PMID:
18031246
12.

Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells.

Levy O, Suter EE, Miller RL, Wessels MR.

Blood. 2006 Aug 15;108(4):1284-90. Epub 2006 Apr 25.

13.

Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects.

Yanagisawa S, Koarai A, Sugiura H, Ichikawa T, Kanda M, Tanaka R, Akamatsu K, Hirano T, Matsunaga K, Minakata Y, Ichinose M.

Respir Res. 2009 Jun 15;10:50. doi: 10.1186/1465-9921-10-50.

14.

TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation.

Larangé A, Antonios D, Pallardy M, Kerdine-Römer S.

J Leukoc Biol. 2009 Apr;85(4):673-83. doi: 10.1189/jlb.0808504. Epub 2009 Jan 21.

PMID:
19164127
15.

The Toll-like receptor 7/8 agonist resiquimod greatly increases the immunostimulatory capacity of human acute myeloid leukemia cells.

Smits EL, Cools N, Lion E, Van Camp K, Ponsaerts P, Berneman ZN, Van Tendeloo VF.

Cancer Immunol Immunother. 2010 Jan;59(1):35-46. doi: 10.1007/s00262-009-0721-8. Epub 2009 May 16.

PMID:
19449004
16.

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.

Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R.

J Immunol. 2011 Apr 15;186(8):4794-804. doi: 10.4049/jimmunol.1000702. Epub 2011 Mar 11.

17.

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells.

Hurst J, Prinz N, Lorenz M, Bauer S, Chapman J, Lackner KJ, von Landenberg P.

Immunobiology. 2009;214(8):683-91. doi: 10.1016/j.imbio.2008.12.003. Epub 2009 Feb 26.

PMID:
19249118
18.

Toll-like receptor 7 selective synthetic oligoribonucleotide agonists: synthesis and structure-activity relationship studies.

Lan T, Dai M, Wang D, Zhu FG, Kandimalla ER, Agrawal S.

J Med Chem. 2009 Nov 12;52(21):6871-9. doi: 10.1021/jm901145s.

PMID:
19824640
19.

RNA recognition via TLR7 and TLR8.

Hornung V, Barchet W, Schlee M, Hartmann G.

Handb Exp Pharmacol. 2008;(183):71-86. Review.

PMID:
18071655
20.

CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands.

Buza J, Benjamin P, Zhu J, Wilson HL, Lipford G, Krieg AM, Babiuk LA, Mutwiri GK.

Vet Immunol Immunopathol. 2008 Dec 15;126(3-4):273-82. doi: 10.1016/j.vetimm.2008.08.001. Epub 2008 Aug 20.

PMID:
18789542

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