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RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G.

Genes Dev. 2007 Dec 1;21(23):3073-84. Epub 2007 Nov 14.


A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.

Islam MN, Paquet N, Fox D 3rd, Dray E, Zheng XF, Klein H, Sung P, Wang W.

J Biol Chem. 2012 Jul 6;287(28):23808-18. doi: 10.1074/jbc.M112.375014. Epub 2012 May 29.


Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.

Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P.

J Biol Chem. 2010 May 21;285(21):15739-45. doi: 10.1074/jbc.M110.110478. Epub 2010 Mar 25.


RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins.

Khadka P, Croteau DL, Bohr VA.

DNA Repair (Amst). 2016 Jan;37:53-66. doi: 10.1016/j.dnarep.2015.11.005. Epub 2015 Dec 2.


Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents.

Hosono Y, Abe T, Ishiai M, Islam MN, Arakawa H, Wang W, Takeda S, Ishii Y, Takata M, Seki M, Enomoto T.

Biochim Biophys Acta. 2014 May;1843(5):1002-12. doi: 10.1016/j.bbamcr.2014.01.005. Epub 2014 Jan 10.


Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.

Bugreev DV, Mazina OM, Mazin AV.

J Biol Chem. 2009 Sep 25;284(39):26349-59. doi: 10.1074/jbc.M109.029371. Epub 2009 Jul 24.


Human RECQL5: guarding the crossroads of DNA replication and transcription and providing backup capability.

Popuri V, Tadokoro T, Croteau DL, Bohr VA.

Crit Rev Biochem Mol Biol. 2013 May-Jun;48(3):289-99. doi: 10.3109/10409238.2013.792770. Epub 2013 Apr 29. Review.


RECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathway.

Kim TM, Son MY, Dodds S, Hu L, Luo G, Hasty P.

Nucleic Acids Res. 2015 Jan;43(2):893-903. doi: 10.1093/nar/gku1334. Epub 2014 Dec 17.


Critical interaction domains between bloom syndrome protein and RAD51.

Bergeron KL, Murphy EL, Brown LW, Almeida KH.

Protein J. 2011 Jan;30(1):1-8. doi: 10.1007/s10930-010-9295-8.


Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.

Wan L, Han J, Liu T, Dong S, Xie F, Chen H, Huang J.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10646-51. doi: 10.1073/pnas.1220921110. Epub 2013 Mar 18.


Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

Antony E, Tomko EJ, Xiao Q, Krejci L, Lohman TM, Ellenberger T.

Mol Cell. 2009 Jul 10;35(1):105-15. doi: 10.1016/j.molcel.2009.05.026.


RECQL5 plays co-operative and complementary roles with WRN syndrome helicase.

Popuri V, Huang J, Ramamoorthy M, Tadokoro T, Croteau DL, Bohr VA.

Nucleic Acids Res. 2013 Jan;41(2):881-99. doi: 10.1093/nar/gks1134. Epub 2012 Nov 23. Erratum in: Nucleic Acids Res. 2016 Dec 6;:.


Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.

Bugreev DV, Yu X, Egelman EH, Mazin AV.

Genes Dev. 2007 Dec 1;21(23):3085-94. Epub 2007 Nov 14.


The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.

Bolterstein E, Rivero R, Marquez M, McVey M.

Genetics. 2014 Jun;197(2):643-52. doi: 10.1534/genetics.114.164228. Epub 2014 Apr 7.


Recruitment and retention dynamics of RECQL5 at DNA double strand break sites.

Popuri V, Ramamoorthy M, Tadokoro T, Singh DK, Karmakar P, Croteau DL, Bohr VA.

DNA Repair (Amst). 2012 Jul 1;11(7):624-35. doi: 10.1016/j.dnarep.2012.05.001. Epub 2012 May 24.


RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.

Seki M, Otsuki M, Ishii Y, Tada S, Enomoto T.

Cell Cycle. 2008 Aug 15;7(16):2472-8. Epub 2008 Aug 18. Review.


Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment.

Hu Y, Lu X, Zhou G, Barnes EL, Luo G.

Mol Biol Cell. 2009 Jan;20(1):114-23. doi: 10.1091/mbc.E08-06-0565. Epub 2008 Nov 5.


Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.

Paliwal S, Kanagaraj R, Sturzenegger A, Burdova K, Janscak P.

Nucleic Acids Res. 2014 Feb;42(4):2380-90. doi: 10.1093/nar/gkt1263. Epub 2013 Dec 6.


Human RECQL5 participates in the removal of endogenous DNA damage.

Tadokoro T, Ramamoorthy M, Popuri V, May A, Tian J, Sykora P, Rybanska I, Wilson DM 3rd, Croteau DL, Bohr VA.

Mol Biol Cell. 2012 Nov;23(21):4273-85. doi: 10.1091/mbc.E12-02-0110. Epub 2012 Sep 12.

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