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Items: 1 to 20 of 83

1.

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.

Li W, Zhou Y, Jentsch JD, Brown RA, Tian X, Ehninger D, Hennah W, Peltonen L, Lönnqvist J, Huttunen MO, Kaprio J, Trachtenberg JT, Silva AJ, Cannon TD.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18280-5. Epub 2007 Nov 2.

2.

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.

Cannon TD, Hennah W, van Erp TG, Thompson PM, Lonnqvist J, Huttunen M, Gasperoni T, Tuulio-Henriksson A, Pirkola T, Toga AW, Kaprio J, Mazziotta J, Peltonen L.

Arch Gen Psychiatry. 2005 Nov;62(11):1205-13.

PMID:
16275808
3.

DISC1 in schizophrenia: genetic mouse models and human genomic imaging.

Johnstone M, Thomson PA, Hall J, McIntosh AM, Lawrie SM, Porteous DJ.

Schizophr Bull. 2011 Jan;37(1):14-20. doi: 10.1093/schbul/sbq135. Epub 2010 Dec 13. Review.

4.

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.

Pletnikov MV, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov MV, Huang H, Mori S, Moran TH, Ross CA.

Mol Psychiatry. 2008 Feb;13(2):173-86, 115. Epub 2007 Sep 11.

PMID:
17848917
5.

A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.

Hennah W, Tuulio-Henriksson A, Paunio T, Ekelund J, Varilo T, Partonen T, Cannon TD, Lönnqvist J, Peltonen L.

Mol Psychiatry. 2005 Dec;10(12):1097-103.

PMID:
16103888
6.

Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.

Schurov IL, Handford EJ, Brandon NJ, Whiting PJ.

Mol Psychiatry. 2004 Dec;9(12):1100-10.

PMID:
15381924
7.

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders.

Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ.

Mol Cell Neurosci. 2004 Jan;25(1):42-55.

PMID:
14962739
8.

Disc1 variation leads to specific alterations in adult neurogenesis.

Chandran JS, Kazanis I, Clapcote SJ, Ogawa F, Millar JK, Porteous DJ, Ffrench-Constant C.

PLoS One. 2014 Oct 1;9(10):e108088. doi: 10.1371/journal.pone.0108088. eCollection 2014.

9.

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.

Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan SL, Chatzi C, He S, Mackie I, Brandon NJ, Marquis KL, Day M, Hurko O, McCaig CD, Riedel G, St Clair D.

J Neurosci. 2008 Oct 22;28(43):10893-904. doi: 10.1523/JNEUROSCI.3299-08.2008.

10.

Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth.

Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M.

Mol Psychiatry. 2003 Jul;8(7):685-94.

PMID:
12874605
11.

Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness.

Hennah W, Thomson P, Peltonen L, Porteous D.

Schizophr Bull. 2006 Jul;32(3):409-16. Epub 2006 May 12. Review.

12.

A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.

Eykelenboom JE, Briggs GJ, Bradshaw NJ, Soares DC, Ogawa F, Christie S, Malavasi EL, Makedonopoulou P, Mackie S, Malloy MP, Wear MA, Blackburn EA, Bramham J, McIntosh AM, Blackwood DH, Muir WJ, Porteous DJ, Millar JK.

Hum Mol Genet. 2012 Aug 1;21(15):3374-86. doi: 10.1093/hmg/dds169. Epub 2012 Apr 30.

13.

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.

Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH.

Cell. 2009 Mar 20;136(6):1017-31. doi: 10.1016/j.cell.2008.12.044.

14.

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.

Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6. Epub 2007 Aug 3.

15.

Disruption of two novel genes by a translocation co-segregating with schizophrenia.

Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ.

Hum Mol Genet. 2000 May 22;9(9):1415-23.

PMID:
10814723
16.

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

Brandon NJ, Schurov I, Camargo LM, Handford EJ, Duran-Jimeniz B, Hunt P, Millar JK, Porteous DJ, Shearman MS, Whiting PJ.

Mol Cell Neurosci. 2005 Apr;28(4):613-24.

PMID:
15797709
17.
18.

Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice.

Lee FH, Zai CC, Cordes SP, Roder JC, Wong AH.

Mol Brain. 2013 Apr 30;6:20. doi: 10.1186/1756-6606-6-20.

19.

DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness.

Millar JK, James R, Brandon NJ, Thomson PA.

Ann Med. 2004;36(5):367-78. Review.

PMID:
15478311
20.

A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder.

Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL.

Mol Psychiatry. 2005 Aug;10(8):758-64.

PMID:
15940305

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