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Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.

Majumdar MK, Askew R, Schelling S, Stedman N, Blanchet T, Hopkins B, Morris EA, Glasson SS.

Arthritis Rheum. 2007 Nov;56(11):3670-4.


Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.

Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, Flannery CR, Kanki K, Wang E, Peluso D, Yang Z, Majumdar MK, Morris EA.

Arthritis Rheum. 2004 Aug;50(8):2547-58.


Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW.

Arthritis Rheum. 2007 Feb;56(2):575-85.


Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.

Ilic MZ, East CJ, Rogerson FM, Fosang AJ, Handley CJ.

J Biol Chem. 2007 Dec 28;282(52):37420-8. Epub 2007 Oct 15.


ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.

Verma P, Dalal K.

J Cell Biochem. 2011 Dec;112(12):3507-14. doi: 10.1002/jcb.23298. Review.


Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

Rogerson FM, Stanton H, East CJ, Golub SB, Tutolo L, Farmer PJ, Fosang AJ.

Arthritis Rheum. 2008 Jun;58(6):1664-73. doi: 10.1002/art.23458.


ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.

Wainwright SD, Bondeson J, Caterson B, Hughes CE.

Arthritis Rheum. 2013 Nov;65(11):2866-75. doi: 10.1002/art.38102.


Aggrecanase and aggrecan degradation in osteoarthritis: a review.

Huang K, Wu LD.

J Int Med Res. 2008 Nov-Dec;36(6):1149-60. Review.


Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis.

Kadri A, Ea HK, Bazille C, Hannouche D, Lioté F, Cohen-Solal ME.

Arthritis Rheum. 2008 Aug;58(8):2379-86. doi: 10.1002/art.23638.


ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

Demircan K, Topcu V, Takigawa T, Akyol S, Yonezawa T, Ozturk G, Ugurcu V, Hasgul R, Yigitoglu MR, Akyol O, McCulloch DR, Hirohata S.

Biomed Res Int. 2014;2014:693746. doi: 10.1155/2014/693746. Epub 2014 Jul 3.


[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].

Ji Q, Zhang Q, Wang Y.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013 Sep;27(9):1080-4. Review. Chinese.


Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T.

Arthritis Rheum. 2009 Jul;60(7):2019-27. doi: 10.1002/art.24654.


In vivo osteoarthritis target validation utilizing genetically-modified mice.

Glasson SS.

Curr Drug Targets. 2007 Feb;8(2):367-76. Review.


The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.

He Y, Zheng Q, Jiang M, Sun S, Christiansen TG, Kassem M, Karsdal MA, Bay-Jensen AC.

PLoS One. 2015 Apr 24;10(4):e0122700. doi: 10.1371/journal.pone.0122700. eCollection 2015.


The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.

He Y, Zheng Q, Simonsen O, Petersen KK, Christiansen TG, Karsdal MA, Bay-Jensen AC.

Matrix Biol. 2013 Apr 24;32(3-4):143-51. doi: 10.1016/j.matbio.2012.12.001. Epub 2013 Jan 4.


Aggrecanases in the human synovial fluid at different stages of osteoarthritis.

Zhang E, Yan X, Zhang M, Chang X, Bai Z, He Y, Yuan Z.

Clin Rheumatol. 2013 Jun;32(6):797-803. doi: 10.1007/s10067-013-2171-0. Epub 2013 Jan 31.


ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

East CJ, Stanton H, Golub SB, Rogerson FM, Fosang AJ.

J Biol Chem. 2007 Mar 23;282(12):8632-40. Epub 2007 Jan 25.


A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers.

Kosasih HJ, Last K, Rogerson FM, Golub SB, Gauci SJ, Russo VC, Stanton H, Wilson R, Lamande SR, Holden P, Fosang AJ.

J Biol Chem. 2016 Feb 12;291(7):3197-208. doi: 10.1074/jbc.M115.704817. Epub 2015 Dec 14.

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