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Items: 1 to 20 of 175

1.

Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization.

Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL.

J Biol Chem. 2007 Dec 21;282(51):37064-73. Epub 2007 Oct 26.

2.

RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization.

Liu YV, Semenza GL.

Cell Cycle. 2007 Mar 15;6(6):656-9. Epub 2007 Mar 7. Review.

PMID:
17361105
3.
4.

Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.

Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL.

J Biol Chem. 2007 Nov 16;282(46):33358-66. Epub 2007 Sep 17.

5.

Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization.

Yu S, Xu Z, Zou C, Wu D, Wang Y, Yao X, Ng CF, Chan FL.

J Pathol. 2014 Dec;234(4):514-25. doi: 10.1002/path.4413. Epub 2014 Sep 15.

PMID:
25065497
6.

PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

Zhou J, Schmid T, Frank R, Brüne B.

J Biol Chem. 2004 Apr 2;279(14):13506-13. Epub 2004 Jan 15.

7.

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.

Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.

Mol Cell. 2005 Feb 18;17(4):503-12.

8.

Activation of hypoxia-induced transcription in normoxia.

Hägg M, Wennström S.

Exp Cell Res. 2005 May 15;306(1):180-91. Epub 2005 Mar 19.

PMID:
15878343
9.

Hypoxia-inducible factor 1 (HIF-1) pathway.

Semenza GL.

Sci STKE. 2007 Oct 9;2007(407):cm8. Review.

10.

SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation.

Amir S, Wang R, Simons JW, Mabjeesh NJ.

J Biol Chem. 2009 Apr 24;284(17):11142-51. doi: 10.1074/jbc.M808348200. Epub 2009 Feb 26.

11.

Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha.

Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL.

J Biol Chem. 2007 Aug 10;282(32):23572-80. Epub 2007 Jun 8.

12.

Phospholipase D2 promotes degradation of hypoxia-inducible factor-1α independent of lipase activity.

Park MH, Bae SS, Choi KY, Min do S.

Exp Mol Med. 2015 Nov 27;47:e196. doi: 10.1038/emm.2015.87.

13.

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.

van de Sluis B, Groot AJ, Vermeulen J, van der Wall E, van Diest PJ, Wijmenga C, Klomp LW, Vooijs M.

PLoS One. 2009 Oct 5;4(10):e7332. doi: 10.1371/journal.pone.0007332.

16.

Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein.

Song X, Yao J, Wang F, Zhou M, Zhou Y, Wang H, Wei L, Zhao L, Li Z, Lu N, Guo Q.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):144-55. doi: 10.1016/j.taap.2013.04.031. Epub 2013 May 23.

PMID:
23707765
17.

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.

Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER.

Oncogene. 2001 Aug 16;20(36):5067-74.

18.

Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness.

He X, Wang J, Messing EM, Wu G.

Oncogene. 2011 Feb 3;30(5):535-47. doi: 10.1038/onc.2010.427. Epub 2010 Sep 27.

PMID:
20871634
20.

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.

Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM.

J Biol Chem. 2002 Aug 16;277(33):29936-44. Epub 2002 Jun 6.

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